literature

HIV mutation literature information.

Persistence of Human Immunodeficiency Virus-1 Drug Resistance Mutations in Proviral Deoxyribonucleic Acid After Virologic Failure of Efavirenz-Containing Antiretroviral Regimens.

PMID: 30863788 2019 Open forum infectious diseases

Method: Nucleoside reverse-transcriptase inhibitor DRMs included M41I/L, D67N/E, K70R, M184V, T215Y/F/C/S, K219Q/E; NNRTI DRM included K103N, Y181C, G190A/S/R, L100I, K101E, V106I/M, Y188H/C/L, M230I/L.

Prevalence and persistence of transmitted drug resistance mutations in the German HIV-1 Seroconverter Study Cohort.

PMID: 30650082 2019 PloS one

Result: For a number of TDRMs, no loss could be observed during the observation period (S1 Table) and, according to their maximal duration of observation, the following TDRMs seem to survive for lengthy periods in the absence of ART: the NRTI resistance mutations D67N (5.9 years), K70R (6.9 years), F77L (10.2 years), T215E (5.9 years) and K219Q (5.9 years), the NNRTI resistance mutations A98G (6.5 years) and Y188L (5.9 years) as well as the PI mutations I54L (5.9 years) and L90M (8.4 years) (S1 Table).

Result: The presence of three or more TDRMs was mainly due to the accum

Development of the R263K Mutation to Dolutegravir in an HIV-1 Subtype D Virus Harboring 3 Class-Drug Resistance.

PMID: 30648124 2019 Open forum infectious diseases

Conclusion: At that time, resistance testing showed NRTI (M184V, T69D, T215S, D67N, K219Q), NNRTI (Y181C, Y188L, H221Y) and PI (L10I, D30N, K20T, L33F, K43T, N88D) resistance, with PI resistance to nelfinavir.

Table: D67N

Drug resistance evolution in patients with human immunodeficiency virus-1 under long-term antiretroviral treatment-failure in Yunnan Province, China.

PMID: 30621727 2019 Virology journal

Discussion: Two clusters were studied here; TAM-1 (M41 L and T215Y) and TAM-2 (D67N, K70R, and K219Q).

Virological outcomes of boosted protease inhibitor-based first-line ART in subjects harbouring thymidine analogue-associated mutations as the sole form of transmitted drug resistance.

PMID: 30544247 2019 The Journal of antimicrobial chemotherapy

Method: TAMs comprised the RT mutations M41L, D67N/G/E, K70R, L210W, T215Y/F/rev and K219Q/E/N/R; T215rev comprised any change from T215 other than T215Y and T215F.

Table: D67N

Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART.

PMID: 30380053 2019 The Journal of antimicrobial chemotherapy

Result: When DRM5% were assessed, double the number of NRTI mutations were found (n = 22), mostly represented by K65R (n = 4/22, 18.2%) and the TAMs D67N and K219EQ (Figure 1b).

Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted Human Immunodeficiency Virus Type 1 Drug Resistance in a Large US Clinic Population.

PMID: 29846534 2019 Clinical infectious diseases

Method: A subset of the NRTI-associated SDRMs were classified as thymidine analogue mutations (TAMs) including M41L, D67N/G, K70R, L210W, T215Y/F, K219Q/E/R/N, and the T215 revertants T215C/D/E/I/S/V (which evolve from T215F/Y in the absence of selective drug pressure).

Molecular Antiretroviral Resistance Markers of Human Immunodeficiency Virus-1 of CRF01_AE Subtype in Bali, Indonesia.

PMID: 30714528 2018 Current HIV research

Discussion: Molecular marker mutations in more than 50% of treatment failure patients were M184V, T215A/Y/F, D67N/G, and M41L.

Discussion: Molecular markers of TAMs, M184V (100%), T215A/Y/F (88.2%), D67N/G (76.5%), and M41L (58.8%), were found in more than 50% of treatment failure patients.

Discussion: There are two clusters of TAMs; cluster 1 includes substitutions of M41L, L210W and T215Y, while cluster 2 of D67N, K70R, T125F and

HIV-1 subtype diversity, transmission networks and transmitted drug resistance amongst acute and early infected MSM populations from Coastal Kenya.

PMID: 30562356 2018 PloS one

Table: D67N

Research on the treatment effects and drug resistances of long-term second-line antiretroviral therapy among HIV-infected patients from Henan Province in China.

PMID: 30442114 2018 BMC infectious diseases

Result: TAM (M41 L, K70R, L210 W, and T215F) and D67N mutations, associated with resistance to TDF, were detected during second-line ART.

Table: D67N

Discussion: TDF was used in the second-line program; the mutations associated with resistance to TDF were K65R, TAM (M41 L, K70R, L210 W, T215F), D67N, K70E, and Y115F.

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