literature

Prevalence and determinants of virological failure, genetic diversity and drug resistance among people living with HIV in a minority area in China: a population-based study.

PMID: 32576136 2020 BMC infectious diseases

Figure: Note: PIs mutations: M46I, I54V, V82A, K20T, L10F/LFI and Q58E/QE; NRTIs mutations: D67N/DN, K70R/KR/T, M184V/MV/I, T215F/FS/TNSY, K219Q, K65R, L74I/LI/LV, Y115F, L210W, M41L and V75I; NNRTIs mutation:

PMID: 32381145 2020 Epidemiology and infection

Result: Among the key DRMs for NRTIs, K65R (1.6%, 5/322) conferred high-level resistance, T69D (0.3%, 1/322) conferred intermediate resistance and M41L (0.6%, 2/322), D67N (0.6%, 2/322) and T215D (0.3%, 1/322) conferred low-level resistance.

HIV-1 Drug Resistance in ART-Naive Individuals in Myanmar.

PMID: 32368103 2020 Infection and drug resistance

Discussion: Some SDRMs, including NRTI-related mutations (M41L, D67E/G/N, K70E/R, M184V, T215any, and K219any) and NNRTI-related mutations (K101E/P, K103N/S, V106A/M, Y181any, G190any, and P225H) were reported in Myanmar.

HIV-1 Sub-Subtype A6: Settings for Normalised Identification and Molecular Epidemiology in the Southern Federal District, Russia.

PMID: 32331438 2020 Viruses

Result: RAMs I54AVPR, L90MPR, M41LRT, D67NPR, and T215FPR were significantly more frequent in subtype G isolates.

HIV-1 Drug Resistance, Distribution of Subtypes, and Drug Resistance-Associated Mutations in Virologic Failure Individuals in Chengdu, Southwest China, 2014-2016.

PMID: 32280691 2020 BioMed research international

Result: The most commonly observed mutations with NRTIs were M184I/V (59.59%, 146/245), K65R (28.16%, 69/245), D67N/G (19.18%, 47/245), K70E/K/R (17.14%, 42/245), Y115F (15.10%, 37/245), L74I/V (11.02%, 27/245), and T215I/Y (8.16%, 20/245).

Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa.

PMID: 32265875 2020 Frontiers in microbiology

Result: D67N occurred in five (5%) patients receiving AZT plus 3TC and in three (3%) patients receiving ABC plus 3TC.

Result: D67N occurred in one (1%) patient receiving both TDF plus 3TC and an FTC plus TDF-based regimen.

Table: D67N

Multidrug-resistant HIV viral rebound during early syphilis: a case report.

PMID: 32264923 2020 BMC infectious diseases

Abstract: A plasma RNA genotype resistance test revealed wild-type virus in the integrase region and protease region (PR), but extensive resistance in the reverse transcriptase (RT) region (M41L, E44D, D67N, K70R, M184V, L210W and T215Y).

Conclusion: A genotype resistance test (GRT) in June 2002 (Trugene HIV-1 Genotyping Assay, Siemens Healthcare Diagnostics GmbH, Eschborn, Germany) showed extensive resistance in the RT region (M41L, E44D, D67

Defective Strand-Displacement DNA Synthesis Due to Accumulation of Thymidine Analogue Resistance Mutations in HIV-2 Reverse Transcriptase.

PMID: 32129987 2020 ACS infectious diseases

Abstract: A mutant human immunodeficiency virus type 2 (HIV-2) RT (M41L/D67N/K70R/S215Y) with low strand displacement activity was identified after screening a panel of purified enzymes, including several antiretroviral drug-resistant HIV-1 and HIV-2 RTs.

Abstract: In HIV-1, resistance to zidovudine and other thymidine analogues is conferred b

Abstract: In contrast, mutants D67N/K70R/S215Y and M41L/D67N/K70R/S215Y were the most defective RTs in reactions carried out with nicked and gapped substrates.

HIV-1 reverse transcriptase and protease mutations for drug-resistance detection among treatment-experienced and naive HIV-infected individuals.

PMID: 32119691 2020 PloS one

Conclusion: SDRMs (D67N and D67E) belonging to the NRTIs class were found in two subjects and SDRMs) K103N and V106A (belonging to the NNRTIs class were found in three subjects.

Result: D67N is a non-polymorphic thymidine analog mutation (TAM) associated with low-level resistance to AZT and Stavudine (D4T).

Result: In the present study, SDRMs belonged to the NRTIs class including D67N and D67E, which were found in two patients.

High prevalence of integrase mutation L74I in West African HIV-1 subtypes prior to integrase inhibitor treatment.

PMID: 32105319 2020 The Journal of antimicrobial chemotherapy

Table: D67N