literature

HIV mutation literature information.

Acquisition of tenofovir-susceptible, emtricitabine-resistant HIV despite high adherence to daily pre-exposure prophylaxis: a case report.

PMID: 30503324 2018 The lancet. HIV

Result: SGS detected minor resistance mutations in the PR gene that were not reported in the standard genotype (D30N (3.6%), G73S (1.8%) and G48E (5.5%).

Transmission of HIV-1 drug resistance mutations within partner-pairs: A cross-sectional study of a primary HIV infection cohort.

PMID: 29584723 2018 PLoS medicine

Table: D30N

[Genetic analysis of the mutations in HIV-1 infected population in Ecuador].

PMID: 29652972 2018 Revista chilena de infectologia

Abstract: Results The most frequent mutations were M184V/I, K101E/P/H, K103N/S, D30N, M46L/I, I54L/M, V82T/F/A/S/L and L90M in adults and F77L, K103N/S, M46L/I, V82T/F/A/S/L and L90M in children.

Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.

PMID: 30288468 2018 ACS omega

Discussion: Interestingly, five of the seven residues adjacent to Leu76 in the PR structure are sites of major resistance mutations, D30N, V32I, I47V, Q58E, and T74P2.

Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy.

PMID: 29977795 2018 African journal of laboratory medicine

Result: The minority PI mutations detected in three of the samples were M46I (2/20) and D30N (1/20) (Table 2).

Table: D30N

Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid.

PMID: 30346745 2018 Journal of the American Chemical Society

Abstract: Importantly, the boronic acid maintains its hydrogen bonds and its affinity for the drug-resistant D30N variant of HIV-1 protease.

Introduction: Because the boronic acid moiety of 1 is anticipated to interact with Asp30, we suspected that D30N HIV-1 protease, which is a common variant that endows resistance, could compromise the affinity of boronic acid 1.

Introduction: For example, the D30N substitution entices darunavir to form a water-bridge between its aniline nitrogen and the nascent asparagine, diminishing affinity by 30-fold.

Comparison between next-generation and Sanger-based sequencing for the detection of transmitted drug-resistance mutations among recently infected HIV-1 patients in Israel, 2000-2014.

PMID: 28799325 2017 Journal of the International AIDS Society

Result: Some of the low-frequency TDRMs identified are consistent with APOBEC-mediated G-to-A editing: the PI M46L/I and D30N, the NRTI D67N and the NNRTI G190E TDRM, as well as the E138K amino substitution, were all related to APOBEC.

Table: D30N

High level of HIV-1 drug resistance mutations in patients with unsuppressed viral loads in rural northern South Africa.

PMID: 28750647 2017 AIDS research and therapy

Result: Two (3.0%) subjects harbored major PI DRM (D30N, M46I and V32I).

Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).

PMID: 28891788 2017 HIV clinical trials

Method: Primary PI-R substitutions assessed were D30N, V32I, L33F, M46I/L, I47A/V, G48V, I50L/V, I54L/M, Q58E, T74P, L76V, V82A/F/L/S/T, I84V, N88S, and L90M in PR.

Computational Studies of a Mechanism for Binding and Drug Resistance in the Wild Type and Four Mutations of HIV-1 Protease with a GRL-0519 Inhibitor.

PMID: 27240358 2016 International journal of molecular sciences

Result: As shown in Figure 5C, the key distances, which can symbolize the binding between residues and inhibitor, are larger in D30N than in the WT.

Result: However, the decomposition of free energy shows that the electrostatic contribution of residue 30 in D30N is more favorable than in the WT.

Result: Of course, the other mutations (D30N, I54M, and V82A) also cause the redistribution of their nearby residues.

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