literature

HIV mutation literature information.

[Genetic analysis of the mutations in HIV-1 infected population in Ecuador].

PMID: 29652972 2018 Revista chilena de infectologia

Abstract: Results The most frequent mutations were M184V/I, K101E/P/H, K103N/S, D30N, M46L/I, I54L/M, V82T/F/A/S/L and L90M in adults and F77L, K103N/S, M46L/I, V82T/F/A/S/L and L90M in children.

Transmission of HIV-1 drug resistance mutations within partner-pairs: A cross-sectional study of a primary HIV infection cohort.

PMID: 29584723 2018 PLoS medicine

Table: D30N

Detection of minority drug resistant mutations in Malawian HIV-1 subtype C-positive patients initiating and on first-line antiretroviral therapy.

PMID: 29977795 2018 African journal of laboratory medicine

Result: The minority PI mutations detected in three of the samples were M46I (2/20) and D30N (1/20) (Table 2).

Table: D30N

Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid.

PMID: 30346745 2018 Journal of the American Chemical Society

Abstract: Importantly, the boronic acid maintains its hydrogen bonds and its affinity for the drug-resistant D30N variant of HIV-1 protease.

Introduction: Because the boronic acid moiety of 1 is anticipated to interact with Asp30, we suspected that D30N HIV-1 protease, which is a common variant that endows resistance, could compromise the affinity of boronic acid 1.

Introduction: For example, the D30N substitution entices darunavir to form a water-bridge between its aniline nitrogen and the nascent asparagine, diminishing affinity by 30-fold.

Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.

PMID: 30288468 2018 ACS omega

Discussion: Interestingly, five of the seven residues adjacent to Leu76 in the PR structure are sites of major resistance mutations, D30N, V32I, I47V, Q58E, and T74P2.

Acquisition of tenofovir-susceptible, emtricitabine-resistant HIV despite high adherence to daily pre-exposure prophylaxis: a case report.

PMID: 30503324 2018 The lancet. HIV

Result: SGS detected minor resistance mutations in the PR gene that were not reported in the standard genotype (D30N (3.6%), G73S (1.8%) and G48E (5.5%).

Comparison between next-generation and Sanger-based sequencing for the detection of transmitted drug-resistance mutations among recently infected HIV-1 patients in Israel, 2000-2014.

PMID: 28799325 2017 Journal of the International AIDS Society

Result: Some of the low-frequency TDRMs identified are consistent with APOBEC-mediated G-to-A editing: the PI M46L/I and D30N, the NRTI D67N and the NNRTI G190E TDRM, as well as the E138K amino substitution, were all related to APOBEC.

Table: D30N

High level of HIV-1 drug resistance mutations in patients with unsuppressed viral loads in rural northern South Africa.

PMID: 28750647 2017 AIDS research and therapy

Result: Two (3.0%) subjects harbored major PI DRM (D30N, M46I and V32I).

Week 48 resistance analysis of Elvitegravir/Cobicistat/Emtricitabine/Tenofovir DF versus Atazanavir + Ritonavir + Emtricitabine/Tenofovir DF in HIV-1 infected women (WAVES study GS-US-236-0128).

PMID: 28891788 2017 HIV clinical trials

Method: Primary PI-R substitutions assessed were D30N, V32I, L33F, M46I/L, I47A/V, G48V, I50L/V, I54L/M, Q58E, T74P, L76V, V82A/F/L/S/T, I84V, N88S, and L90M in PR.

Binding of Clinical Inhibitors to a Model Precursor of a Rationally Selected Multidrug Resistant HIV-1 Protease Is Significantly Weaker Than That to the Released Mature Enzyme.

PMID: 27039930 2016 Biochemistry

Result: PR20 cluster 1 encompasses three mutations contiguous to the active site, D30N, V32I and L33F, that are not present in PRS17.

Result: In contrast, mutations D30N, V32I, L33F, I47V, I54L, and I84V are present in PR20 but not in PRS17.

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