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 HIV mutation literature information.


  Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.
 PMID: 26107265       2015       PloS one
Result: Sixteen out of 23 (70%) had NNRTI mutations (Y181C/I/D: 10; K103N: 6; V106A/I: 3; Y188C/L: 2; K101Q/E: 2; M230L: 1; P225H: 1; A98G: 1; V108I: 1; F227L: 1; K238T: 1), and 10 had >1 NNRTI mutation.
Table: A98G


  Development of Nevirapine Resistance in Children Exposed to the Prevention of Mother-to-Child HIV-1 Transmission Programme in Maputo, Mozambique.
 PMID: 26161559       2015       PloS one
Method: A NVP RAM was considered if at least one of the following genetic changes in reverse transcriptase was detected: A98G, K101E, K101H, K101P, K103N, V106A, V106M, V108I, Y181C, Y181V, Y188L and G190A.
Result: There were also multiple occurrences of V108I (n = 6), A98G (n = 6), K101E (n = 4), V106A (n = 4), K101P (n = 1).


  Comparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission.
 PMID: 26469189       2015       PloS one
Method: M19921) and a mutant pNL4.3 derived clone that harbours seven resistance mutations in the RT (M41L, A62V, A98G, K103N, V118I, L210W, T215Y).


  HIV Drug Resistance Surveillance in Honduras after a Decade of Widespread Antiretroviral Therapy.
 PMID: 26558396       2015       PloS one
Table: A98G


  Outcome of patients on second line antiretroviral therapy under programmatic condition in India.
 PMID: 26572102       2015       BMC infectious diseases
Table: A98G


  HIV-1 Drug Resistance Mutations: Potential Applications for Point-of-Care Genotypic Resistance Testing.
 PMID: 26717411       2015       PloS one
Result: A98G and K101E were the most common non-major transmitted NNRTI DRMs.


  Prevalence of drug resistance in human immunodeficiency virus type 1-infected treatment-naive children in Pune, India.
 PMID: 24387706       2014       AIDS research and human retroviruses
Abstract: Nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations, namely A98G and K103N, were observed in two separate sequences.


  Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.
 PMID: 24586665       2014       PloS one
Result: Among mutations associated with NNRTI resistance, A98G accounted for 1.9%, and decreased the NVP and EFV sensitivity.
Result: The drug resistance mutation loci included A71V, D67H, T69N, K70R, T215F, K219E, A98G, V179D, and Y181C, with HNHIV97 and HNHIV113 clustered together.
Table: A98G


  Phenotypic and genotypic analyses to guide selection of reverse transcriptase inhibitors in second-line HIV therapy following extended virological failure in Uganda.
 PMID: 24633208       2014       The Journal of antimicrobial chemotherapy
Result: Individual mutations observed were G190AS (n = 8; 47%), Y181CV (n = 6; 35%), K101I (n = 3; 18%), A98G (n = 2; 12%), K103N (n = 2; 12%) and V108I (n = 1; 6%).


  Identification of the critical sites of NNRTI-resistance in reverse transcriptase of HIV-1 CRF_BC strains.
 PMID: 24743727       2014       PloS one
Result: For example, M184V and K103N had 12 (A98G, K101Q, K103N, I132L, R135L, T139K, T139R, Y181C, Y188L, G190A, H221Y, and L228R) and 6 (R135L, T139K, T139R, Y181C, H221Y, L228R) target mutations, respectively.
Result: In addition to the three previously reported



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