Result: 5A), while V32I, V32C, and A71V showed large delays in the initial cleavage of Gag.
Result: For example, L10S had the lowest fitness score, but processed Gag faster than any other mutant variant while A71V had the highest fitness score among the mutant variants but showed a large delay in Gag cleavage.
Result: The largest increase in proficiency we observed was about 2-fold for Q92I cutting PR-RT and for A71V cutting TF-PR.
Result: Two of the mutations in this set (V32I and
HIV-1 Drug Resistance, Distribution of Subtypes, and Drug Resistance-Associated Mutations in Virologic Failure Individuals in Chengdu, Southwest China, 2014-2016.
Result: The most frequent mutations were L10I/V (32), A71I/T/V (28), and K20I/R (26), among which L10I/V and A71I/T/V are mutations that do not affect drug susceptibility and K20I/R were predicted to have potential resistance to NFV.
Discussion:
Discussion: In this study, among the PI-associated DR mutations detected, K20I/R and T74S were mainly found in CRF01_AE while A71I/T/V, Q58E, and V82I were frequently observed in CRF07_BC, indicating that the presence of different mutations may vary among different subtypes.
Highly drug-resistant HIV-1 protease reveals decreased intra-subunit interactions due to clusters of mutations.
Abstract: In a distal beta-sheet, mutations G73T and A71V coordinate with accessory mutations to bring about shifts that propagate throughout the subunit.
Introduction: Two mutations in PRS5B have a major association with drug-resistance (M46L and I84V), while nine are classified as minor drug resistance mutations (L10I, V11I, M36I, I54V, I62V, I63P, I64V, A71V, and G73T).
Result: Comparison of both PRS5B/PI structures with analogous wild-type complexes reveals how G73T
HIV-1 Gag mutations alone are sufficient to reduce darunavir susceptibility during virological failure to boosted PI therapy.
PMID: 32556165
2020
The Journal of antimicrobial chemotherapy
Result: Only non-polymorphic and polymorphic PI accessory selected mutations were found in PT1 (K20T), PT4 (A71V) and PT5 (L10V).
Table: A71V
Drug resistance evolution in patients with human immunodeficiency virus-1 under long-term antiretroviral treatment-failure in Yunnan Province, China.
Introduction: Mutations at I50 are often selected together with A71V mutation, which is distal from the active site but compensates for the loss of enzymatic fitness.
Introduction: Thermodynamics and structural studies of DRV binding to I50V/L and A71V mutations have revealed significant
Result: A71V, a compensatory mutation that is far from the active site and almost always observed with I50V, restores the functionality to WT level (Km = 73 +- 9 muM), as previously reported.
Result: A time-course gel shift assay confirmed the catalytic activity of I50V single mutant, and the rescued activity of I50V/A71V variant in cleaving purified Gag polyprotein [Figure S1].
HIV Viral Rebound Due to a Possible Drug-Drug Interaction between Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide and Calcium-Containing Products: Report of 2 Cases.
PMID: 30798679
2019
Journal of the International Association of Providers of AIDS Care
Conclusion: The HIV genotype at this time reported the RT gene mutations M184V and L100L/F, conferring resistance to emtricitabine and lamivudine, and protease gene mutations L10V, M36I/M, K43R, L63P, H69Y, A71A/V, and I93L.
Antiretroviral drug resistance mutations among patients failing first-line treatment in Hanoi, Vietnam.
Introduction: One such example is the A71V mutation, a secondary mutation that, when observed in conjunction with I50V/L, acts to restore a balance between catalytic efficiency and inhibitor binding.
Mechanism of Darunavir (DRV)'s High Genetic Barrier to HIV-1 Resistance: A Key V32I Substitution in Protease Rarely Occurs, but Once It Occurs, It Predisposes HIV-1 To Develop DRV Resistance.
Result: 1) contained the V32I substitution, although other substitutions such as L10F, L33F, M46I, A71V, and I84V had been acquired in a subset of the six clones.
Result: A71V predisposes HIV-1 to its acquisition of high-level DRV resistance.
Result: Furthermore, when the A71V substitution is combined with V32I and I54M or V32I and I84V (both of which by themselves appear to be hypersensitive on their own), the resultant HIV-1 yields high-level DRV resistance (Table 2).
Result: However, the addition of A71V to these two clones, gen
HIV mutation literature information.
PMID: 
2021
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