literature

HIV mutation literature information.

Relatively high prevalence of drug resistance among antiretroviral-naive patients from Henan, Central China.

PMID: 23800338 2014 AIDS research and human retroviruses

Abstract: The unexpectedly high percentage of drug resistance in Henan province is mainly due to the prevalence of minor mutations in the protease and integrase regions, especially A71T/V and L68V/I/IM/LV.

Characteristics of HIV-1 natural drug resistance-associated mutations in former paid blood donors in Henan Province, China.

PMID: 24586665 2014 PloS one

Discussion: Results from the HIV-1 drug resistance mutation research by the International AIDS Society-USA (updated in March 2013) have revealed that PI resistance mutation sites are L10I, K20M, V32I, M36I, M46I/L, I47V/A, I50V, Q58E, A71V, G73S, V82A/F/T, I84V, L89V,L90M; NRTIs resistance mutations are M41L, A62V,

PMID: 24629078 2014 BMC bioinformatics

Result: According to the IAS-USA, the mutations associated with drug resistance, with a p >10%, were L10I, M36I, I62V, L63P, I64V, A71V/T, V77I, L90M, and I93L.

Effects of PRE and POST therapy drug-pressure selected mutations on HIV-1 protease conformational sampling.

PMID: 24983495 2014 FEBS letters

5Result: Both L63P and A71V are located away from the active site cavity (Figure 1) in a region of the protein that has b

Result: 3.4 Effects of single point mutation L63P on conformational ensemble and comparison to A71V.

Result: A71V is a common secondary mutation seen in multi-drug resistant constructs, and studies suggest this mutation stabilizes the dimer when primary mutations arise.

The prevalence of transmitted HIV drug resistance among MSM in Anhui province, China.

PMID: 25035709 2014 AIDS research and therapy

Result: However, some accessory mutations that did not affect susceptibility to ARV drugs were found in the protease gene, including L10I/L/V (3.0%; 4/133), V11I/V (3.0%; 4/133), L33F (2.3%; 3/133), and A71A/V/T (12.8%; 17/133).

Discussion: Other commonly observed mutations were T69A/N/S, V179E, L10I/L/V, V11I/V, L33F, and A71A/T/V; none of these mutations is known to confer drug resistance to NRTIs, NNRTIs, or PIs.

Discussion: The prese

Systematic molecular dynamics, MM-PBSA, and ab initio approaches to the saquinavir resistance mechanism in HIV-1 PR due to 11 double and multiple mutations.

PMID: 25036111 2014 The journal of physical chemistry. B

Abstract: Herein, we extend our analysis, which includes seven double (G48V-V82A, L10I-G48V, G48V-L90M, I84V-L90M, L10I-V82A, L10I-L63P, A71V-G73S) and four multiple (L10I-L63P-A71V, L10I-G48V-V82A, G73S-I84V-L90M,

Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.

PMID: 25355911 2014 Proc Natl Acad Sci U S A

Abstract: To understand the molecular basis of this protease-substrate coevolution, we solved the crystal structures of drug resistant I50V/A71V HIV-1 protease with p1-p6 substrates bearing coevolved mutations.

A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF.

PMID: 25108107 2014 Journal of molecular graphics & modelling

Introduction: The multidrug-resistant (MDR)-769 HIV-1 protease consists of amino acid substitutions: L10I, M36V, M46L, I54V, I62V, L63P, A71V, V82A, I84V and L90M.

Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.

PMID: 25575025 2014 Retrovirology

Table: A71V

HIV-1 diversity, transmission dynamics and primary drug resistance in Angola.

PMID: 25479241 2014 PloS one

Result: A71T was found in one patient infected with a subtype C virus and A71V was found in two patients infect with subtype D.

Result: A71T/V are polymorphisms that occur in 2-3% of untreated individuals but the frequency increases in patients receiving PIs.