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 HIV mutation literature information.


  Drug resistance patterns and virus re-suppression among HIV-1 subtype C infected patients receiving non-nucleoside reverse transcriptase inhibitors in South Africa.
 PMID: 21927716       2011       Journal of AIDS & clinical research
Result: Overall, 8/38 (21%) had one or more TAMs, three had A62V or V75I and only one patient had K65R.


  Resistance patterns selected by nevirapine vs. efavirenz in HIV-infected patients failing first-line antiretroviral treatment: a bayesian analysis.
 PMID: 22132100       2011       PloS one
Result: More specifically, TDF, when compared with d4T, was found strongly associated with greater risk of mutations Y115F and K65R (PP[OR>1]>99%), and, with less clear evidence (PP[OR>1]>92) with greater risk of mutations Y181I, V179F, and A62V (Figure 2B).


  Low-abundance HIV species and their impact on mutational profiles in patients with virological failure on once-daily abacavir/lamivudine/zidovudine and tenofovir.
 PMID: 20008905       2010       The Journal of antimicrobial chemotherapy
Result: Mutations detected by CG at baseline that could have impacted response to one or more study drugs included mutations at T215, K70E, D67G, M184V and the multi-NRTI Q151M-associated mutations A62V and F77L.
Result: Seven of the VF subjects at baseline had resistance mutation-containing low-abundance viral species (including one of more of the following: A62V, F77L, K70E, T215A, T215S, D67G, M184V or K219Q) with the potential to impact response to one or more st


  Characterization of HIV type 1 genotypes and drug resistance mutations among drug-naive HIV type 1-infected patients in Northern Vietnam.
 PMID: 20156106       2010       AIDS research and human retroviruses
Abstract: Major reverse-transcriptase inhibitor (RTI) resistance mutations were found in seven patients (4.5%), four of whom had single mutations: A62V (nucleoside RTI resistance mutation) in two cases and K103N and Y181C (nonnucleoside RTI resistance mutation) in one case each.


  The HIV-1 Reverse Transcriptase A62V Mutation Influences Replication Fidelity and Viral Fitness in the Context of Multi-Drug-Resistant Mutations.
 PMID: 20455467       2010       Voprosy virusologii
Abstract: According to the presence or absence of mutations V77I in protease and/or A62V in reverse transcriptase, the patients were divided into 2 study groups.
Abstract: Immunological study showed that the median CD4+, CD8+, and CD4/CD8 in the patients infected with virus variants containing mutations V77I and/or A62V were increased by 25, 20, and 16%, respectively.


  The human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor resistance mutation I132M confers hypersensitivity to nucleoside analogs.
 PMID: 19193782       2009       Journal of virology
Abstract: This decrease in viral replication capacity could be partially or completely compensated for by the A62V or L214I mutation, respectively.


  Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance.
 PMID: 19358668       2009       The Journal of infectious diseases
Result: 3.1 +- 0.3 mumol/L, for Q151M and Q151M+3, respectively), indicating that A62V, F77L, and Y116F do not enhance AZT resistance in HIV-2.
Result: Although A62V, F77L, and Y116F increase the level of Q151M-mediated AZT resistance in HIV-1, the Q151M and Q151M+3 variants of HIV-2ROD exhibited comparable sensitivity to the drug (mean EC50 [+-SD], 5.2 +- 2.3 vs.
Result: Surprisingly, the dose-response profile of Q151M HIV-2ROD was comparable to that of the highly resistant Q151M/A62V/ PMID: 19644383       2009       Journal of acquired immune deficiency syndromes (1999)
Result: Among 21 patients primarily on TDF containing ART, the following mutations were observed: M184V, M184I, S68G, A62V and Y115F and K219E.
Result: The following mutations were observed in significantly more patients with K65R: S68G, A62V, Y115F, Q151M complex, T69del and K219R [all p<0.01].


  Epidemiological networks and drug resistance of HIV type 1 in Krasnoyarsk region, Russia.
 PMID: 19689192       2009       AIDS research and human retroviruses
Abstract: Most viruses (75%) had an A62V mutation in reverse transcriptase, specific for HIV-1 strains in Russia.


  Thymidine analogue resistance suppression by V75I of HIV-1 reverse transcriptase: effects of substituting valine 75 on stavudine excision and discrimination.
 PMID: 19801659       2009       The Journal of biological chemistry
Abstract: M41L/A62V/T69SSS/K70R/T215Y), the introduction of V75I led to a significant decrease of its ATP-dependent excision activity on AZT-, d4T-, and acyclovir-terminated primers.
Abstract: Recombinant HIV-1 containing the M41L/A62V/T69SSS/K70R/V75I/T215Y RT showed 18.3- and 1.5-fold increased susceptibility to AZT and d4T, respectively, in comparison with virus containing the M41L/A62V/T69SSS/K70R



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