literature

HIV mutation literature information.

Genotypic Characterization of Human Immunodeficiency Virus Type 1 Derived from Antiretroviral Therapy-Naive Individuals Residing in Sorong, West Papua.

PMID: 27009513 2016 AIDS research and human retroviruses

Abstract: Major drug resistance-associated mutations for PR inhibitors were not detected; however, mutations for the RT inhibitors, A62V and E138A, appeared in a few samples, indicating the possible emergence of transmitted HIV-1 drug resistance in Sorong, West Papua.

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.

PMID: 26850643 2016 Nucleic acids research

Result: A62V and S68G restore the impaired nucleotide incorporation of the K65R mutation, thus improving the replication capacity of the virus.

Result: Finally, in July 2008 four out of six TAMs relevant for highly efficient AZTMP excision (M41L, D67N, T215Y and K219E, missing K70R and L210W) as well as four out of five discrimination mutations (A62V, V75I, F116Y and Q151M, lacking F77I) were present.

Result: Furthermore, the accessory discrimination mutations A62V a

Comparison of genotypic and virtual phenotypic drug resistance interpretations with laboratory-based phenotypes among CRF01_AE and subtype B HIV-infected individuals.

PMID: 26147742 2016 Journal of medical virology

Result: Protease (PR) RAMs detected from this outlier sample were M46I, I47V and I84V, and reverse transcriptase (RT) RAMs were A62V, D67N, K70R, V75I, F116Y, Q151M and K219Q.

Result: RT RAMs were A62V, D67N, V75I, F77L, K101H, Y115F, F

Effectiveness of a Treatment Switch to Nevirapine plus Tenofovir and Emtricitabine (or Lamivudine) in Adults with HIV-1 Suppressed Viremia.

PMID: 26107265 2015 PloS one

Result: Six patients selected A62V, with K65R selected in 4 of them, and none with Q151M or T69 insertions.

Table: A62V

Characterization of HIV drug resistance mutations among patients failing first-line antiretroviral therapy from a tertiary referral center in Lusaka, Zambia.

PMID: 25754408 2015 Journal of medical virology

Result: A wide range of mutations conferring multi-NRTI resistance were also observed, including M41L (n = 7, 10%), A62V (n = 15, 22%), D67N (n = 10, 15%), K70R (n = 10, 15%), V75I (n = 2, 3%), F77L (n = 1, 1%), Y115F (n = 6, 9%), F116Y (n = 1, 1%), Q151M (n = 1, 1%), L210W (n = 3, 4%), T215Y/F (n = 7, 10%) and (n = 5, 7%), and K219Q/E (n = 4, 6%) and (n = 7, 10%).

Genetic Diversity and Drug Resistance Among Antiretroviral Treatment-Failed Individuals from 2010 to 2012 in Honghe, China.

PMID: 25919896 2015 AIDS research and human retroviruses

Abstract: Mutations such as M184V, A62V, T69Ins, K103N, Y181C, and G190A were common among the ART-failed individuals.

Abstract: The frequencies of M184V, A62V, and K103N were 20.5%, 11.0%, and 23.6%, respectively.

Phylogenetic analysis of HIV-1 subtypes and drug resistance profile among treatment-naive people in Kuwait.

PMID: 25976289 2015 Journal of medical virology

Abstract: A62V and A98G were non-polymorphic resistance-associated mutations (RAMs) detected in the RT region of two and three patients, respectively.

Comparison of 454 Ultra-Deep Sequencing and Allele-Specific Real-Time PCR with Regard to the Detection of Emerging Drug-Resistant Minor HIV-1 Variants after Antiretroviral Prophylaxis for Vertical Transmission.

PMID: 26469189 2015 PloS one

Method: M19921) and a mutant pNL4.3 derived clone that harbours seven resistance mutations in the RT (M41L, A62V, A98G, K103N, V118I, L210W, T215Y).

Resistance against Integrase Strand Transfer Inhibitors and Relevance to HIV Persistence.

PMID: 26198244 2015 Viruses

Table: A62A/V

MOLECULAR TRACING OF HETEROSEXUAL HIV-1 TRANSMISSION IN GEORGIA.

PMID: 26355316 2015 Georgian medical news

Abstract: Of these 16 events, viruses from 14 pairs had genetic distance less than 0.015.Mutation A62V was seen in samples from 5 pairs, of them samples from 4 pairs additionally had V77I mutation.

Browser Board

Co-occurred Entities

Filtrator