literature

HIV mutation literature information.

Prevalence of HIV-1 drug resistance in Eastern European and Central Asian countries.

PMID: 35061671 2022 PloS one

Result: M41L in addition to A62V was found in Belarus (3/158; 1.9%) and Tajikistan (2/54; 3.7%).

Result: A62V is a polymorphic mutation for sub-subtype A6 and was the most frequent NRTI DRM in Russia (174/465; 37.4%), Armenia (34/120; 28.3%), Azerbaijan (24/96; 25.0%), Belarus (21/158; 13.3%), and Uzbekistan (48/178; 27.0%).

Result: In Tajikistan, the prevalence of A62V was found to be low (2/54; 3.7%).

Correlation of HIV-1 drug resistant mutations and virologic failure.

PMID: 34584606 2021 The Pan African medical journal

Table: A62V

HIV-1 Drug Resistance and Genetic Transmission Networks Among MSM Failing Antiretroviral Therapy in South China 2014-2019.

PMID: 34377002 2021 Infection and drug resistance

Table: A62V

Nucleoside Reverse-Transcriptase Inhibitor Resistance Mutations Predict Virological Failure in Human Immunodeficiency Virus-Positive Patients During Lamivudine Plus Dolutegravir Maintenance Therapy in Clinical Practice.

PMID: 34327247 2021 Open forum infectious diseases

Table: A62V

Temporal Trends in HIV-1 Mutations Used for the Surveillance of Transmitted Drug Resistance.

PMID: 34064774 2021 Viruses

Method: Tenofovir-associated mutations were defined as A62V, K65R/N/E, S68G/N/D, T69 deletions, and K70E/Q/N/T/S/G.

Result: A62V had a naive prevalence below 0.2% in each of the other subtypes and increased in prevalence from 4.1 to 6.9% since 2009.

Result: A62V, another tenofovir-associated mutation, was not considered a candidate SDRM because it had a prevalence of 6.5% in subtype A sequences owing to a founder effect among subtype A6 sequences, one of the dominant variants in countries of the former Soviet Union.

HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial.

PMID: 34762770 2021 Journal of the International AIDS Society

Result: Two samples had nucleoside/tide reverse transcriptase inhibitor (NRTI) mutations; one with E44D and a second with A62A/V with the NNRTI mutation H221Y.

Natural polymorphisms in HIV-1 CRF01_AE strain and profile of acquired drug resistance mutations in a long-term combination treatment cohort in northeastern China.

PMID: 32102660 2020 BMC infectious diseases

Result: The NRTI-associated DRMs detected at TF time point in descending order included K65R (57.1%), M184 V/I (47.6%), S68G (26.2%), A62V (14.3%), K70E/R (9.5%), and Y115F (9.5%).

Human Immunodeficiency Virus-1 Viral Load Is Elevated in Individuals With Reverse-Transcriptase Mutation M184V/I During Virological Failure of First-Line Antiretroviral Therapy and Is Associated With Compensatory Mutation L74I.

PMID: 31774913 2020 The Journal of infectious diseases

Result: Many of these mutations have previously been associated with drug resistance to tenofovir, either directly (K65R, K70E) or as compensatory mutations for K65R (A62V, S68N, F155Y).

HIV-1 acquired drug resistance to integrase inhibitors in a cohort of antiretroviral therapy multi-experienced Mexican patients failing to raltegravir: a cross-sectional study.

PMID: 32041622 2020 AIDS research and therapy

Table: A62V

Expanded Spectrum of Antiretroviral-Selected Mutations in Human Immunodeficiency Virus Type 2.

PMID: 31965175 2020 The Journal of infectious diseases

Abstract: In RT, 9 nonpolymorphic TSMs occurred in >=10 persons: K40R, A62V, K70R, Y115F, Q151M, M184VI, S215Y.

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