literature

HIV mutation literature information.

HIV-1 drug resistance among individuals who seroconverted in the ASPIRE dapivirine ring trial.

PMID: 34762770 2021 Journal of the International AIDS Society

Result: Amino acid changes, including G335D, N348I, T369I, A371V, and A376S associated with DPV or NNRTI resistance were not detected in the connection or RNAse H domains of HIV-1 RT.

Frequent cross-resistance to rilpivirine among subtype C HIV-1 from first-line antiretroviral therapy failures in South Africa.

PMID: 29566538 2018 Antiviral chemistry & chemotherapy

Method: Additional subtype C resistance-associated C-terminal mutations/polymorphisms observed were G335D (86%), A371V (19%) and A376S (12%).

Characterization of Nucleoside Reverse Transcriptase Inhibitor-Associated Mutations in the RNase H Region of HIV-1 Subtype C Infected Individuals.

PMID: 29117130 2017 Viruses

Discussion: In combination with TAMs and A371V, Q509L mutation reduced AZT susceptibility about 10- to 50-fold in vitro.

Drug resistance-related mutations T369V/I in the connection subdomain of HIV-1 reverse transcriptase severely impair viral fitness.

PMID: 28279801 2017 Virus research

Abstract: Drug-resistance related mutations (DRMs) T369V/I and A371V in the connection subdomain (CN) of reverse transcriptase (RT) occur at higher frequencies in the individuals experiencing antiretroviral therapy failure.

Abstract: Here, we evaluated the effects of T369V/I and A371V on viral fitness, in the presence or in the absence of thymidine analogue resistance-associated mutations (TAMs) and assessed the effect of potential RT structure-related mechanism on change in viral fitness.

Early selection of resistance-associated mutations in HIV-1 RT C-terminal domains across different subtypes: role of the genetic barrier to resistance.

PMID: 24948706 2014 The Journal of antimicrobial chemotherapy

Abstract: A371V was common to treatment-naive isolates.

Abstract: A371V was selected in subtypes B and C, but is a signature in subtype A.

Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance.

PMID: 23068886 2013 Virology

Introduction: We further analyzed 450 subtype B isolates from the Stanford University HIV Drug Resistance Database and showed that 9 CN mutations (I326V, R358K, G359S, A360T, A360V, K366R, A371V, K390R and A400T) and 6 RH mutations (I506L, K512R, K527N, K530R, and Q457K) were positively associated with NRTI or AZT monotherapy exposure.

Result: Database analysis showed A400T to be a common polymorphism in subtype C, while

Screening for and verification of novel mutations associated with drug resistance in the HIV type 1 subtype B(') in China.

PMID: 23144802 2012 PloS one

Abstract: RESULTS: 7 mutations at 6 positions of the RT region, D123E, V292I, K366R, T369A, T369V, A371V and I375V, occurred more frequently in the ART failure group than the naive

Discussion: Mutations T369V/I and A371V emerged in the drug-naive patients, but the frequencies were relatively low and there was a significant difference between the subtype B and the subtype C.

Discussion: Our findings showed that the resistance level was enhanced by 2.08~7.14 FCs to NNRTIs when the mutations T369V or A371V occurred alone.

Zidovudine (AZT) monotherapy selects for the A360V mutation in the connection domain of HIV-1 reverse transcriptase.

PMID: 22363673 2012 PloS one

Introduction: The goal of the current study was to determine whether AZT monotherapy in HIV-1 infected participants selects the A371V, Q509L or other mutations in the connection or RNase H domains of RT.

Introduction: Two novel mutations - A371V in the connection domain and Q509L in the RNase H domain - were selected in combination with D67N, K70R and T215F that together conferred

Result: The connection domain mutation A371V was more frequent in last-on-therapy samples compared to pre-therapy samples, but this difference was not statistically significant (p = 0.25).

Connection domain mutations during antiretroviral treatment failure in Mali: frequencies and impact on reverse transcriptase inhibitor activity.

PMID: 22828721 2012 Journal of acquired immune deficiency syndromes (1999)

Result: In univariate analysis, G335D (OR 19.9 [95%CI 5.1-78.2], P <0.005) and A371V (OR 10.8 [3.9-30.0], P <0.005) were significantly associated with CRF02_AG, and wit

Discussion: In subtype B, CD mutations that have been associated with resistance include E312Q, G333E/D, G335D, N3481, A360I/V, V365I, T369I, A371V and A376S [6-9], but these associations are controversial; other investigators did not find a major detrimental effect of N3481, R356K, R358K, A360V or A371V on response to ART.

[Screening program on novel drug resistance mutations of subtype B' in human immunodeficiency virus type 1 in China].

PMID: 21569736 2011 Zhonghua liu xing bing xue za zhi

Abstract: RESULTS: Frequencies of 7 mutations at 6 positions, D123E, V292I, K366R, T369A, T369V, A371V and I375V, 2 at DNA polymerase domain and 5 at connection domain of reverse transcriptase (RT) were higher in the treated patients than in the untreated patients.

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