literature

HIV mutation literature information.

Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms.

PMID: 18547911 2008 The Journal of biological chemistry

Introduction: Most importantly, many of these mutations, including mutations N348I, A360I/V, and A371V, in the connection domain of HIV-1 RT were identified in clinical samples of HIV-infected individuals.

Result: Other mutations (A360I and A360S) were observed only rarely.

HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision.

PMID: 18667707 2008 Proc Natl Acad Sci U S A

Abstract: We found that cn mutations G335C/D, N348I, A360I/V, V365I, and A376S decreased primary and secondary RNase H cleavages.

Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance.

PMID: 17179211 2007 Proc Natl Acad Sci U S A

Abstract: Mutational analysis showed that amino acid substitutions E312Q, G335C/D, N348I, A360I/V, V365I, and A376S were associated strongly with the observed increase in AZT resistance; several of these mutations also decreased RT template switching, suggesting that they alter the predicted balance between nucleotide excision and template RNA degradation.

N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance.

PMID: 18052601 2007 PLoS medicine

Introduction: Mutational studies revealed the presence of several connection domain mutations, including E312Q, G335C/D, N348I, A360I/V, V365I, and A376S, that were associated with AZT resistance.

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