Abstract: The sequence analysis of Gag146 in 261 chronically HIV-1-infected Japanese showed the accumulation of the A146P mutation in HLA-B*48:01(+) individuals.
Abstract: These findings together indicate that the A146P mutant is accumulating in Japanese by selection by GI8-specific CTLs.
Abstract: We herein demonstrated Gag140-147(GI8) to be the optimal epitope rather than LI10 and that GI8-specific T cells failed to recognize the A146P mutant virus-infected cells.
Abstract: We previously showed the possibility that Gag A146P, which is an escape mutant from HLA-B*57-restricted CTLs, was selected by HLA-B*48:01-restricted Gag138-147(LI10)-
Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein.
Abstract: To answer the question, the RRCs were quantified for escape mutations in three immunodominant HLA-B*57/B*5801 epitopes in capsid: A146P in IW9 (RRC(P146) = 0.91), A163G in KF11 (RRC(G163) = 0.89), and T242N in TW10 (RRC(N242) = 0.86).
Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.
PMID: 15067030
2004
The Journal of experimental medicine
Abstract: The A146P mutation prevented NH2-terminal trimming of the optimal epitope by the endoplasmic reticulum aminopeptidase I.
HIV mutation literature information.
PMID: 
2020
The Journal of antimicrobial chemotherapy
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