Result: Exceptionally, 13
S mutations presented the higher distributions (p<0.1) in the
HCC group:
F20S (8.2% vs 1%, p = 0.015),
D33G (4.1% vs 0%, p = 0.039), (
T47A/E/V/K (18.4% vs 7.1%, p = 0.025),
R79H (6.1% vs 0%, p = 0.007),
L88P (4.1% vs 0%, p = 0.039),
P120S/T (on the MHR region, 16.3% vs 6.6%, p = 0.042),
G145R (6.1% vs 1%, p = 0.055),
S174N (6.1% vs 0.5%, p = 0.026),
V190A (6.1% vs 0.5%, p = 0.026),
P203R (8.2% vs 2%, p = 0.052),
Y206H/F/C (6.1% vs 1.5%, p = 0.094),
PMID: 32312174
2020
Emerging microbes & infections
Abstract: Results confirmed by multivariable analysis correcting for patients'demographics, HBV-DNA, ALT and infection-status.In genotype-D, specific C-terminus mutations (
V190A-
S204N-
Y206C-
Y206F-
S210N) significantly correlate with
HBsAg<1000IU/ml(P-value from <0.001 to 0.04).
Abstract: These mutations lie in divergent pathways involving other
HBsAg C-terminus mutations:
V190A +
F220L (Phi = 0.41, P = 0.003),
S204N +
L205P (Phi = 0.36, P = 0.005),
Y206F +
S210R (Phi = 0.47, P < 0.001) and
S210N +
HBV mutation literature information.
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