Abstract: Mutations were found in the
S gene, including
Y100C,
Y103I,
G145R, and
L175S, which can affect the detection of
HBsAg.
Result: Several mutations associated with the interference of
HBsAg detection, such as mutations in the major hydrophilic region (MHR), including
Q129H,
T131I,
M133L/S/T,
F134L,
T143M, and
G145R, and mutations outside the MHR, including
Y100C,
L175S, and
Y103I, were found in
HBV mutation literature information.
PMID: 
2021
BMC infectious diseases
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