Result: P120Q/S (8.7%) and Q129H (4.3%) substitutions were detected and recognized to have a major impact on HBsAg detection, while Y100S (8.7%) substitution was observed responsible in OBIs for lack of excretion of HBsAg.
Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.
Discussion: found no reactivity of HBsAg using two commercial diagnostic assays whose sequences had simultaneous mutations at various positions, including an amino acid at 100 (Y100S), and this may have been due to mutations at other sites (T118V/R122K/M133I/Y134N/P142S/S143L/G145K).
Occult HBV among Anti-HBc Alone: Mutation Analysis of an HBV Surface Gene and Pre-S Gene.
Abstract: Site-directed-mutagenesis-corrected mutations reversed HBsAg excretion to pattern 1 and, when introduced into a control clone, induced pattern 2 except for Y100S.
Abstract: The substitution M75T, Y100S, or P178R was present in 4/6 pattern 2 OBI clones.
Occult hepatitis B virus infection in anti-HBs-positive infants born to HBsAg-positive mothers in China.
Discussion: identified the OBI-associated mutations Y100S, T116N, R122P, S143L and S167L from a large-sample, blood-donor study.
Detection of lamivudine-resistant variants and mutations related to reduced antigenicity of HBsAg in individuals from the cities of Santos and Sao Paulo, Brazil.
Abstract: By co-variation analysis, correlations were observed for R122P+S167L (phi=0.68, P=0.01), T116N+S143L (phi=0.53, P=0.03), and Y100S+S143L (phi=0.67, p<0.001).
Abstract: Even more, Y100S and Y100S+S143L supernatants show no detectable-HBsAg (experiments in quadruplicate).
HBV mutation literature information.
PMID: 
2019
BMC infectious diseases
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