Abstract: An analysis of the effect of
Cp mutants on intracellular or extracellular viral protein production indicated that the
W62R mutation in
Cp had a critical impact on the reduction of
HBcAg and
HBeAg production during HBV replication, whereas
P50H and/or
S74G mutations played a limited role in influencing viral protein production invivo.
Abstract: CONCLUSIONS:
W62R and its combination mutations in HBV
Cp might massively affect
HBcAg and
HBeAg production during viral replication, which, in turn, might contribute to the occurrence of
OBI.
HBV mutation literature information.
PMID: 
2021
Journal of hepatology
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