literature

HBV mutation literature information.

Analysis of the Physicochemical Properties, Replication and Pathophysiology of a Massively Glycosylated Hepatitis B Virus HBsAg Escape Mutant.

PMID: 34835134 2021 Viruses

Abstract: In this study, we constructed an HBV-producing vector that expresses W3S HBs (pHB-W3S) along with a wild-type HBV-producing plasmid (pHB-WT) in order to analyze the physicochemical properties, replication, and antiviral drug response of the mutant.

Abstract: Transfection of either pHB-WT or W3S into HepG2 cells yielded similar CsCl density profiles and eAg expression, as did transfection of a glycosylation defective mutant, pHB-W3S (N146G), in which a glycosylation site at the 146aa asparagine (N) site of HBs was mutated to glycine (G).

Abstract: Virion secretion, however, seemed to be severely impaired in cases of pHB-W3S and pHB-W3S (N14

Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.

PMID: 28045894 2017 PloS one

Abstract: Using the same commercial immunoassay kit, we found that the single mutants, K120P and D123T, were marginally reactive, whereas W3S-aW1S and the double mutant, K120P/D123T, exhibited antigenicity roughly equivalent to the wild-type wako1S.

Introduction: W1S but not W3S was detected with commercial ELISA kits.

Introduction: In this study, we cloned the ORFs of three wild-type HBsAgs, designated W1S, W3S and adr4 (all of which were isolated from HBV-infected patients) and constructed a total of 19 synthetic mutants into a mammalian expression vector.

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