Introduction: In theory, its overlapping
S gene should have two types of mutation at amino acid 172, which include
rtA181T/
sW172L (TGG CTC TTA CTC) mutant coding substituted
HBsAg protein and
rtA181T/
sW172*(TGG CTC TGA CTC) mutant coding truncated
HBsAg protein.
Introduction: Our previously studies showed that the replication capacity of HBV
rtA181T/
sW172* mutant was higher than that of HBV
rtA181T