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 HBV mutation literature information.


  Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.
 PMID: 35415256       2022       Clinical and experimental hepatology
Discussion: They also found that F24Y, E64D, and V91S/T mutations were located in the T-cell epitope regions, and E77Q, A80I/T/V, and L116I were located within the B-cell epitope regions.


  The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
 PMID: 30406036       2018       Frontiers in cellular and infection microbiology
Abstract: Six of the seven significant core mutations that were identified in this study were located within immuno-active epitopes; E77Q, A80I/T/V, and L116I were located within B-cell epitopes, and F24Y, E64D, and V91S/T were located within T-cell epitopes.
Result: Furthermore, mutation V91T, substituting valine for threonine at the same core position as V91S, was present in large percentage of patients in the AC+LC+HCC group; this prevalence (91.12%) was significantly higher than was seen in the IC group (9.44%; p < 0.0001).|mgd



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