literature

HBV mutation literature information.

Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.

PMID: 35415256 2022 Clinical and experimental hepatology

Table: V27I

Mutations in Core Gene Region of Hepatitis B Virus in Patients with Chronic Hepatitis B.

PMID: 29739114 2018 Clinical laboratory

Abstract: Some types of mutations (V27I, R47H, Y132I, R174STOP, S181P, Q182K) were only detected in subjects with liver cirrhosis.

Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.

PMID: 24587360 2014 PloS one

Abstract: The main amino acid substitutions within the MHC class II restricted T-cell epitope of HBcAg includes the T12S (15.8%) and T67N (12.3%) mutation and the V27I (10.5%) mutation in the MHC class I restricted T-cell epitope.

Result: Several amino acid substitutions were found within the immune-active region of the HBV core gene including the T12S (9/57, 15.8%) and T67N (7/57, 12.3%) mutation in the MHC class II restricted T-cell epitope of HBV core protein and the V27I (6/57, 10.5%) mutation in the MHC class I restricted T-cell epitope.

Figure: The major mutations in the MHC class I restricted (amino acids 18-27, 88-96, 130-140, 141-151) and MHC class II-restricted (amino

The high prevalence of the I27 mutant HBcAg18-27 epitope in Chinese HBV-infected patients and its cross-reactivity with the V27 prototype epitope.

PMID: 17900990 2007 Clinical immunology (Orlando, Fla.)

Abstract: Approximately 93.3% (98/105) of the core genes that were sequenced contained mutations with amino acid substitution at position 27 of the core protein: a mutation from a valine to an isoleucine (V27I).

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