literature

HBV mutation literature information.

Reactivation of Occult Hepatitis B Virus Infection During Long-Term Entecavir Antiviral Therapy.

PMID: 35359734 2022 Frontiers in microbiology

Table: V207M

Fast and Sensitive Real-Time PCR Detection of Major Antiviral-Drug Resistance Mutations in Chronic Hepatitis B Patients by Use of a Predesigned Panel of Locked-Nucleic-Acid TaqMan Probes.

PMID: 34319801 2021 Journal of clinical microbiology

Abstract: Single-point mt for LMV and ADF resistance were detected in 57.7% and 54.1% of the child and adult samples, respectively, with rtV207M (children, 42.3%; adults, 36.7%) and rtN238T/A (children, 15.4%; adults, 16.3%) being the most frequent mt in these populations.

Abstract: We developed a novel real-time PCR assay that simultaneously evaluates 11 major nucleos(t)ide antiviral (NA) drug resistance mutations (mt) in chronic hepatitis B patients (CHB), including L180M, M204I/V, and V207M (lamivudine [LMV] resistance), N/H238A/T (adefovir [ADF] resistance), which are circula

COLD-PCR Method for Early Detection of Antiviral Drug-Resistance Mutations in Treatment-Naive Children with Chronic Hepatitis B.

PMID: 32708399 2020 Diagnostics (Basel, Switzerland)

Abstract: Multiple-point mt were found only in 8 cases (5.6%): 6 children carried double mt (rtV207M + rtL229V; rtV207M + rtI233V; rtV207I + rtV207M x 2 cases; rtV207M + rtS213T; rtN238A + rtS256G) relating to LMV or/and ADF resistance and 3 children carried triple mt (

Prevalence of Potential Resistance Related Variants Among Chinese Chronic Hepatitis B Patients Not Receiving Nucleos(T)ide Analogues.

PMID: 32765014 2020 Infection and drug resistance

Table: V207I/L/M

Viral quasispecies of hepatitis B virus in patients with YMDD mutation and lamivudine resistance may not predict the efficacy of lamivudine/adefovir rescue therapy.

PMID: 30906435 2019 Experimental and therapeutic medicine

Result: Common and frequent mutations identified in the cohort of the present study included rtL80V/I, rtV84M, rtL91I, rtN118H/D/T, rtT128A, rtL180M, rtT184L/S/A, rtV191I, rtS202G, rtV207I/M, rtS213T

[Determination of reverse transcriptase inhibitor nucleoside analogue resistance profile in pretreatment phase of patients with viral hepatitis B].

PMID: 31130120 2019 Mikrobiyoloji bulteni

Abstract: However, potential drug resistance mutations such as rtR164R, rtG165D/A, rtG172Q, rtS176N, rtF178V, rtA181G, rtS185N/G/C, rtV207M, rtQ215H/S, rtL231V, rtI233K, rt

Potential resistant mutations within HBV reverse transcriptase sequences in nucleos(t)ide analogues-experienced patients with hepatitis B virus infection.

PMID: 31147594 2019 Scientific reports

Result: In this study, non-classical mutations were observed in 29 patients who suffering from virological breakthrough and without classical mutations (Table 4) at 9 sites (V191I, V207I/M, S213T, E218D, F221Y, I224V, L229V, N/H238 and R242D).

Result: Out of 24 mutations of L229 (Table 3), 18 were associated to M204I or V; 2 coexisted with F221Y (Table 4); 2 were associated to A181T; 2 were associated to V207M (Table 4) and N236V, respectively.

Result: These sites could be classified into the following groups:

PMID: 31189581 2019 Journal of clinical microbiology

Table: V207M

Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.

PMID: 26457811 2015 PloS one

Result: Amino acid substitutions in mother include T16I, R41S, V44A,N53S, H55R, W58R, N76D, S81T, V103I, G107E, N121I, I122L, N123D, Q125K, H126Y, N134D, N139H, N139Q, Y158H, I163V, F178L, S185N, V207M

Molecular characterization of hepatitis B virus in liver disease patients and asymptomatic carriers of the virus in Sudan.

PMID: 23865777 2013 BMC infectious diseases

Result: In the reverse transcriptase domain of the polymerase, the following mutations were detected: rtA194T in SDAC049 (genotype D), rtV207M in SDAC020 (genotype D), rtS213T in SDAC063 and SDAC098 (genotype D), SDAC002, SDAC121 and SDAC004 (genotype E), rtV214A in SDAC059 (genotype E) and rtS215Q in SDAC049 and SDAC090 (genotype D).

Discussion: The reverse transcriptase mutations rtA194T, rtV207M

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