literature

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Result: Exceptionally, 13 S mutations presented the higher distributions (p<0.1) in the HCC group: F20S (8.2% vs 1%, p = 0.015), D33G (4.1% vs 0%, p = 0.039), (T47A/E/V/K (18.4% vs 7.1%, p = 0.025), R79H (6.1% vs 0%, p = 0.007), L88P (4.1% vs 0%, p = 0.039), P120S/T (on the MHR region, 16.3% vs 6.6%, p = 0.042), G145R (6.1% vs 1%, p = 0.055), S174N (6.1% vs 0.5%, p = 0.026), V190A (6.1% vs 0.5%, p = 0.026), P203R (8.2% vs 2%, p = 0.052), Y206H/F/C (6.1% vs 1.5%, p = 0.094),

PMID: 32312174 2020 Emerging microbes & infections

Abstract: Results confirmed by multivariable analysis correcting for patients'demographics, HBV-DNA, ALT and infection-status.In genotype-D, specific C-terminus mutations (V190A-S204N-Y206C-Y206F-S210N) significantly correlate with HBsAg<1000IU/ml(P-value from <0.001 to 0.04).

Abstract: These mutations lie in divergent pathways involving other HBsAg C-terminus mutations: V190A + F220L (Phi = 0.41, P = 0.003), S204N + L205P (Phi = 0.36, P = 0.005), Y206F + S210R (Phi = 0.47, P < 0.001) and S210N +

Molecular and serological characterization of occult hepatitis B among blood donors in Maputo, Mozambique.

PMID: 32997000 2020 Memorias do Instituto Oswaldo Cruz

Table: V190A

Case Report: Application of hepatitis B virus (HBV) deep sequencing to distinguish between acute and chronic infection.

PMID: 33458253 2020 Wellcome open research

Conclusion: Mutations at amino acid level were also seen in surface antigen (V190A and T127P), both of which have been associated with CHB-AR in the context of immunosuppression ( Table 1).

Table: V190A

Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression.

PMID: 25418031 2015 Hepatology (Baltimore, Md.)

Abstract: The remaining five (C48G-V96A-L175S-G185E-V190A) are localized in class I/II-restricted T-cell epitopes, suggesting a role in HBV escape from T-cell-mediated responses.

Characterization of naturally occurring and Lamivudine-induced surface gene mutants of hepatitis B virus in patients with chronic hepatitis B in India.

PMID: 16428891 2006 Intervirology

Abstract: Following lamivudine therapy, 14 of 57 (24.5%) patients developed 16 types of S-gene mutations (sP120S, sA128V, sS143L, sW182St., sT189I, sV190A, sS193L, sI195M, sW196L, sW196St., sS207R,