HBV mutation literature information.


  Dried blood spot sampling for hepatitis B virus quantification, sequencing and mutation detection.
 PMID: 35102169       2022       Scientific reports
Table: V168A


  Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.
 PMID: 35390033       2022       PloS one
Table: V168A


  Novel hepatitis B virus surface antigen mutations associated with occult genotype B hepatitis B virus infection affect HBsAg detection.
 PMID: 32336003       2020       Journal of viral hepatitis
Abstract: Five of the ten mutations (E2G, D144E, G145R, V168A and S174N) strongly decreased extracellular HBsAg level (P < .05) in the transfection system.
Abstract: Hence, ten mutations were associated with genotype B occult HBV infection; E2G and V168A were novel mutations which we confirmed significantly affect HBsAg detection.
Abstract: Ten occult infection-related mutations (E2G, Q101R, K122R, M133T, D144E, G145R


  The sK122R mutation of hepatitis B virus (HBV) is associated with occult HBV infection: Analysis of a large cohort of Chinese patients.
 PMID: 32763811       2020       Journal of clinical virology
Abstract: Specifically, the prevalence rates of sT118 K, sK122R, and sV168A were increased in OBI patients.


  Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
 PMID: 31269905       2019       BMC infectious diseases
Abstract: Most OBI strains were wild-type HBV, but some substitutions V168A, S174 N, V177A, Q129R/L/H, G145A/R in S region of genotype B (OBIB) and T47K/V/A, P49H/L, Q101R/H/K, S174 N, L175S, V177A, T118 M/R/K, G145R/A/K/E, R160K/N in S region of genotype C (OBIC) strains were identified in high frequency.
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  Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.
 PMID: 29408943       2018       PloS one
Table: V168A


  Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors.
 PMID: 27882070       2016       Hepatitis monthly
Abstract: Mutations in the S region of HBV DNA included S114T, G119R, P120S, T125M, C139Y, T140I, C147W, T148A, A159V/G, E164D, V168A, and R169C.
Result: Variants were found in 30.4% (21/69) of cases with OBI and included S114T, G119R, P120S, T125M, C139Y, T140I,


  Occult HBV Infection May Be Transmitted through Close Contact and Manifest as an Overt Infection.
 PMID: 26457811       2015       PloS one
Result: Amino acid substitution mutations in the major hydrophilic region predicted from eleven clones of HBV from the mother's sample include D99N, T131N, F161S and V168A.


  Hepatitis B surface antigen variants in voluntary blood donors in Nanjing, China.
 PMID: 22500577       2012       Virology journal
Result: D99N, Q101R/H, L109I, I110N, T115S, S117T, P120S, K122R, S126T/A, P127H, A128V, Q129R/H/L, G130E, T131N/A, M133T/L/S, F134R/I/L, T143M, A159V, F161Y, W163G, E164G, V168A


  Genotyping and molecular characterization of hepatitis B virus from human immunodeficiency virus-infected individuals in southern Africa.
 PMID: 23029487       2012       PloS one
Abstract: Isolates with sV168A occurred more frequently in participants with viral loads >200 IU per ml (p<0.05) and only sS174N occurred more frequently in HBsAg(-ve) than in HBsAg(+ve) individuals (p<0.05).
Abstract: The following mutations occurred significantly more frequently in HBV isolated in this study than in strains of the same cluster of the phylogenetic tree: ps1F25L, ps1V88L/A; ps2Q10R, ps2 R48K/T, ps2A5



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