Discussion: In the present study eight different (
P90F,
K91W/R,
V92A/P,
L93P, H94-,
K95S,
R96C,
T97A) substitutions and deletion mutations were found in this region that may affect the viral replication and cell cycle and might play a role in the development of the advanced form of
liver disease.
Discussion: Likewise, three mutations
T97A,
L100G, and
S101F were reported in the HNF4 site which were more prevalent in
HCC groups (12.5%, 50%, and 62% respectively) as compared to other t