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 HBV mutation literature information.


  Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.
 PMID: 35415256       2022       Clinical and experimental hepatology
Table: T67N


  The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.
 PMID: 30406036       2018       Frontiers in cellular and infection microbiology
Discussion: Previously, a study of HBV core variability under antiviral therapy reported the presence of the E64D mutation during the course of HBV infection, and stated that this substitution significantly reduced T-cell proliferation in vitro when it occurred with mutation T67N (Homs et al.,).


  Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.
 PMID: 24587360       2014       PloS one
Abstract: The main amino acid substitutions within the MHC class II restricted T-cell epitope of HBcAg includes the T12S (15.8%) and T67N (12.3%) mutation and the V27I (10.5%) mutation in the MHC class I restricted T-cell epitope.
Result: Several amino acid substitutions were found within the immune-active region of the HBV core gene including the T12S (9/57, 15.8%) and T67N (7/57, 12.3%) mutation in the MHC class II restricted T-cell epitope of HBV core protein and the V27I (6/57, 10.5%) mutation in the MHC class I restricted T-cell epitope.
Discussion: The major mutations include the T12S, V27I and


  Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
 PMID: 25333524       2014       PloS one
Result: Overall three mutations in Th epitope (T12S, S35T, T67N) and one in CTL epitope (T147C) of core showed significant association with HCC (p<0.05) (Table 3).
Table: T67N
Discussion: Koschel et al showed that deletion at codon 12 is defective in virion secretion while other two mutations S35T, T67N might be able to evade the host immune response for their persistence at low levels.


  Naturally occurring core immune-escape and carboxy-terminal mutations runcations in patients with e antigen negative chronic hepatitis B.
 PMID: 26201521       2012       Hepatology international
Abstract: When frequency of core immune escape mutations was compared among CHB and decompensated patients, and cT12S: (27 vs. 10%, p < 0.05), cS21T (16 vs. 1.35%, p < 0.01), cT67P/N: (20 vs. 4%, p < 0.001), cE113D (11.37 vs. 1.35%, p < 0.05), and cP130T/Q (7 vs. 0%, p < 0.001) mutations were found to be significantly higher in decompensated patients.



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