Result: However, in the case of genotype D, the A12S, P33S, P46S, and T36A/D/G mutations were more highly represented in one specific group, CI patients.
rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 Genome.
Abstract: We also found that there are a total of 19 signature single nucleotide polymorphisms (SNPs), of which 2 and 17 nonsynonymous mutation types were specific to rt269L and rt269I, respectively: Of these, most are HBeAg negative infections (preC-W28*, X-V5M and V131I), lowered HBV DNA or virion production (C-I97F/L, rtM204I/V) or preexisting nucleot(s)ide analog resistance (NAr) (rtN139K/H, rtM204I/V and
Mutation profiling of the hepatitis B virus strains circulating in North Indian population.
Abstract: Drug Associated mutations were detected in 22% of the patient group and T36A and G50R mutations in X gene were found to be associated with HCC.
Abstract: Few mutations in X gene (T36A and G50R) showed high frequency of association with HCC.
Conclusion: Few mutations in X gene (T36A and G50R) showed high frequency of association with HCC, however further studies are required to validate the findings.
HBV mutation literature information.
PMID: 
2021
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