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 HBV mutation literature information.


  Molecular characterization of hepatitis B virus in Vietnam.
 PMID: 28859616       2017       BMC infectious diseases
Method: The preS2/S1 sequences were analyzed for preS1 deletion, preS1 mutations (A2962G, C3026A/T, C2964A, and C3116T), preS2 start codon deletion, and preS2 mutations (T31C, T53C, A162G, and T531C/G).


  Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.
 PMID: 29287068       2017       PloS one
Discussion: T31C, located in the spacer domain, is a highly variable region of polymerase.


  Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in Qidong, China.
 PMID: 24849936       2014       PloS one
Abstract: HCC patients also had a lower frequency of T31C mutation in pre-S2 gene, compared with control subjects (0.524; 95% CI 0.280-0.982).
Result: Among these nine hot spot mutations, pre-S deletions, pre-S start codon mutations, T31C, and T53C mutations were significantly associated with HCC, showing adjusted ORs from 0.524 to 3.199 (Table 2).
Result: These included well-studied mutations (e.g., the pre-S2 start codon mutation and pre-S deletion) and less well-defined mutations (e.g., C3026A or T in pre-S1


  Distribution and hepatocellular carcinoma-related viral properties of hepatitis B virus genotypes in Mainland China: a community-based study.
 PMID: 20160279       2010       Cancer epidemiology, biomarkers & prevention
Abstract: In contrast to G1896A, PreS deletion, T31C, T1753V, and A1762T/G1764A were more frequent in subgenotype C2 than in subgenotype B2.


  Associations between hepatitis B virus mutations and the risk of hepatocellular carcinoma: a meta-analysis.
 PMID: 19574418       2009       Journal of the National Cancer Institute
Table: T31C
Discussion: Other mutations that have been shown to be statistically significantly associated with the risk of HCC, such as those at T31C, T53C, G1613A, A1703G, G1719T, C1726A, and G1730C, were not included because few patients had these mutations.


  Genotype-specific genomic markers associated with primary hepatomas, based on complete genomic sequencing of hepatitis B virus.
 PMID: 18216102       2008       Journal of virology
Abstract: HCC-related mutations T31C, T53C, and A1499G were associated with HBV subgenotype Ce, and mutations G1613A, G1899A, T2170C/G, and T2441C were associated with HBV subgenotype Cs.



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