ViMRT
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 HBV mutation literature information.


  Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.
 PMID: 33562603       2021       International journal of molecular sciences
Abstract: A cell-based phenotypic assay revealed that the rtT301A mutation dramatically impaired the replication ability with meaningful reduction in sensitivity to tenofovir in hepatoma cell lines.
Abstract: However, attenuated viral replication by the rtT301A mutation was significantly restored in primary human hepatocytes (PHHs).
Abstract: Interestingly, a threonine to alanine mutation at the 301 amino acid position of the reverse-transcriptase (RT) domain, (rtT301A), was commonly accompanied with CYELMVI at a high rate (72.7%).



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