Result: Our unbiased approach led us to the discovery of additional variants highly associated with patient's HBeAg status: G1899A, A1838G, T2045A, G2345A, G2352A, T2441C, A2189C, T2443C, C1962A, G2237C, and others (LRT; p < 9.55 x 10-13.
Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.
PMID: 27727182
2016
International journal of molecular sciences
Result: Meanwhile, the frequencies of hot-spot mutations in the C gene increased in the HCC group, from 6.1% (deletion), 15.2% (T1938C), 11.1% (C2002T), 13.1% (T2045A), 35.4% (A2159G), 40.4% (A2189Y), 10.1% (G2203W), and 22.2% (C2288R) in HCC cases to 2.0%, 7.1%, 7.1%, 14.3%, 20.4%, 22.4%, 2.0%, and 11.2% in controls, respectively.
Hepatitis B virus core variants modify natural course of viral infection and hepatocellular carcinoma progression.
Abstract: The longitudinal study further showed that the appearance of 2 such variants (T1938C and T2045A) was preceded by long-term diminished viral load and decreased rate of liver abnormalities and was significantly less frequent in individuals with a prolonged immune clearance phase that associated with spectrum of liver disease than those in inactive carrier or reactivation phase.
HBV mutation literature information.
PMID: 
2019
Scientific reports
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