Abstract: Further analysis showed that the age of G1721A/A1775G/T1858C containing combined mutation group was significantly lower than that of the non-mutation group [(4.58 +- 2.53) years vs.
The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.
PMID: 29628773
2018
Cancer management and research
Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion) were confirmed by the BLAST analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi).
Result: According to different mutation regions, A1752T/G, T1753C,
Broad Range of Hepatitis B Virus (HBV) Patterns, Dual Circulation of Quasi-Subgenotype A3 and HBV/E and Heterogeneous HBV Mutations in HIV-Positive Patients in Gabon.
Abstract: In addition, G1721A/A1775G/T1858C combined mutation was associated with higher viral load and lower age distribution.
Abstract: Several combined mutations were obviously highly distributed in children with chronic HBV genotype C infection, such as G1721A/A1775G/T1858C triple mutation; a novel combined mutation type, exclusively detected in children with chronic HBV genotype C infection.
Result: Combined mutation characteristics were also found in other hotspot mutation positions from genotype C sequences of children, such as G1721A (G1721A/A1775G
Associations between hepatitis B virus basal core promoter/pre-core region mutations and the risk of acute-on-chronic liver failure: a meta-analysis.
Method: The following mutation sites were also detected in the included studies: G1613A, C1653T, 1752G, T1754V, T1753V/A1762T/G1764A, T1758C, G1764A/C1766T/T1768A, T1770A, 1773 T, G1775A, C1799V, T1800C, T1803C, G1809T, A1814C, A1837G, A1846G, T1853C, PMID: 26564702
2015
Zhonghua liu xing bing xue za zhi
Abstract: CONCLUSION: The present investigation showed that BCP A1762T/G1764A, A1775G and Pre-C T1858C mutations are correlated with the incidence of HCC in Fusui county of Guangxi.
Abstract: Multiple logistic regression analysis indicated that A1762T/G1764A and T1858C mutations are the risk factors for the development of HCC (OR = 5.459, 95% CI: 1.397-21.332, P = 0.015; OR = 3.881, 95% CI: 1.462-10.305, P = 0.006).
Abstract: RESULTS: The mutation rates of the A1762T/
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Abstract: BCP_T1753C, core_T147C, surface_L213I had contributed significantly in the disease progression to HCC (p < 0.05) in HBeAg positive patients whereas precore_T1858C, core_I116L, core_P130Q and preS1_S98T in HBeAg negative patients.
Result: The occurrence of precore mutation, T1858C was
Association of Hepatitis B Virus Mutations of A1846T and C1913A/G With Acute-on-Chronic Liver Failure Development From Different Underlying Chronic Liver Diseases.
Result: In addition, since BCP/PC mutations of T1754G, T1758C, C1766T, T1768A, G1862T, and T1858C were observed only in 7, 5, 7, 4, 1, and 4 of ACLF patients, respectively, these mutations were not included in further analysis.
A multicentre molecular analysis of hepatitis B and blood-borne virus coinfections in Viet Nam.
Figure: The mutation T1858C was identified only in genotype C viruses.
A case-control study on sequence variations in the enhancer II/core promoter/precore and X genes of hepatitis B virus in patients with hepatocellular carcinoma.
HBV mutation literature information.
PMID: 
2020
Zhonghua gan zang bing za zhi
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