literature

HBV mutation literature information.

HBx mutations promote hepatoma cell migration through the Wnt/beta-catenin signaling pathway.

PMID: 27420729 2016 Cancer science

Introduction: A1762T/G1764A (TA) mutations in the core promoter, which overlap with the HBx gene, are found commonly in HCC and are independent risk factors for the progression of HCC during chronic HBV infection.12 In vivo studies suggest that the TA mutant increases the replication capacity of HBV and suppresses HBeAg serum levels.13 A1762T/G1764A mutations are also predictors of postoperative survival in patients with HBV-related HCC.14 A1762T/T1764A<

Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.

PMID: 24788140 2014 PloS one

Discussion: Another possibility to explain the rationality of A987G is that this mutation may be in linkage disequilibrium with other well-defined HCC-related mutations such as pre-S deletion, the BCP/EnhII region mutations C1653T, T1753A/G, C1762T, and T1764A, and the precore mutations G1896A, G1899A.

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