literature

HBV mutation literature information.

Pre-S/Surface and Core Promoter/Precore Mutations in Chronic Hepatitis B Patients with Severe Acute Exacerbation.

PMID: 30835025 2019 Digestive diseases and sciences

Abstract: Cox regression analysis showed that independent predictors for mortality at week 24 of treatment in SAE patients were higher international normalized ratio, the presence of ascites, and T1753C/A/G mutations.

Abstract: The SAE patients with T1753C/A/G mutations had a higher rate of acute-on-chronic liver failure (P = 0.006) and higher MELD score (P = 0.018) than those without T1753C/A/G mutations.

Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B.

PMID: 31359359 2019 Virus genes

Abstract: Based on NGS, the prevalence of T1753V (T1753C/A/G) and A1762T/G1764A variants were significantly lower in responders compared to non-responders (8.3% vs.

Mutations of Basal core promoter and precore regions in hepatitis B virus genotypes B and C.

PMID: 25741368 2015 Hepatitis monthly

Table: T1753G

Novel natural mutations in the hepatitis B virus reverse transcriptase domain associated with hepatocellular carcinoma.

PMID: 24788140 2014 PloS one

Introduction: Over the past few years, we defined that a high prevalence of the HBV C1 genotype, pre-S deletion and pre-S2 start codon mutation, C1653T, T1753A/G, C1766T, and T1768A mutations in the BCP/EnhII region, and A2159G, A2189C, and G2203W in the core gene are associated with HCC in Qidong.

Discussion: Another possibility to explain the rationality of A987G is that this mutation may be in linkage disequilibrium with other well-defined

PMID: 23886144 2013 Asian Pacific journal of cancer prevention

Abstract: The prevalences of T1753C/A/G and A1762T/G1764A mutations in the basal core promotor (BCP) region were significantly higher in the HCC group compared to the non-HCC group.

Hepatitis B virus gene mutations in liver diseases: a report from New Delhi.

PMID: 22720023 2012 PloS one

Table: T1753C/G

Frequency and clinical significance of core promoter and precore region mutations in Tunisian patients infected chronically with hepatitis B.

PMID: 22997074 2012 Journal of medical virology

Abstract: A1679G/C, T1753C/G/A, A1762T/G and A1762T-G1764A were more prevalent in older patients.

Evolution of hepatitis B virus sequence from a liver transplant recipient with rapid breakthrough despite hepatitis B immune globulin prophylaxis and lamivudine therapy.

PMID: 12966541 2003 Journal of medical virology

Abstract: Sequence analysis of full-length viral genome before transplantation revealed many point mutations as compared with a wild-type genotype C sequence, including the T1753G/A1762T/G1764A triple mutation in the basal core promoter and the G1896A nonsense mutation in the precore region.

Prevalence of mutations in core promoter/precore region in Japanese patients with chronic hepatitis B virus infection.

PMID: 9824137 1998 Digestive diseases and sciences

Abstract: Furthermore, a mutation at nucleotide 1753 from T to C or G was frequently found in anti-HBe positive patients and was often accompanied by the double mutation.

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