literature

The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma.

PMID: 35223517 2022 Frontiers in oncology

Abstract: Wild-type HBx (WT-HBx) and four HBx mutants (M1, A1762T/G1764A; M2, T1674G+T1753C+A1762T/G1764A; M3, C1653T+T1674G+A1762T/G1764A; and Ct-HBx, carboxylic acid-terminal truncated HBx) were delivered into Sleeping Beauty (SB) mouse models.

Introduction: Here, we investigated tumorigenic effects of combo HBx mutations (A1762T/G1764A,

Abstract: Mutations T1753C, A1762T, G1764A, C1766T, T1768A G1896A, G2092T and T2107C were associated with acute liver failure and progression to chronic hepatitis.

Complete genome analysis of hepatitis B virus in Qinghai-Tibet plateau: the geographical distribution, genetic diversity, and co-existence of HBsAg and anti-HBs antibodies.

PMID: 32532295 2020 Virology journal

Abstract: Clinical prognosis-related genetic variations such as nucleotide mutation T1762/A1764 (27.93%), A2189C (12.85%), G1613A (8.94%), T1753C (8.38%), T53C (4.47%) T3098C (1.68%) and PreS deletion (2.23%) were detected in CD recombinants.

Result: In addition, T1753C, another mutation in BCP, was found at a frequency of 4.6% in CD1 and 18.4% in CD2 (P = 0.003).

Table: T1753C

Pre-S/Surface and Core Promoter/Precore Mutations in Chronic Hepatitis B Patients with Severe Acute Exacerbation.

PMID: 30835025 2019 Digestive diseases and sciences

Abstract: Cox regression analysis showed that independent predictors for mortality at week 24 of treatment in SAE patients were higher international normalized ratio, the presence of ascites, and T1753C/A/G mutations.

Abstract: The SAE patients with T1753C/A/G mutations had a higher rate of acute-on-chronic liver failure (P = 0.006) and higher MELD score (P = 0.018) than those without T1753C/A/G mutations.

Large-scale viral genome analysis identifies novel clinical associations between hepatitis B virus and chronically infected patients.

PMID: 31324819 2019 Scientific reports

Discussion: Previous studies described additional variants in the core promoter including C1653T, T1753C, A1762T, and G1764A and their correlation with the downregulation of precore mRNA.

Discussion: While our study did not identify any significant association with A1762T and G1764A, we found T1753C to be strongly associated with HBeAg status in our dataset (Supplementary Table 2).

Next generation sequencing identifies baseline viral mutants associated with treatment response to pegylated interferon in HBeAg-positive chronic hepatitis B.

PMID: 31359359 2019 Virus genes

Abstract: Based on NGS, the prevalence of T1753V (T1753C/A/G) and A1762T/G1764A variants were significantly lower in responders compared to non-responders (8.3% vs.

Molecular characterization of hepatitis B virus X gene in HIV-positive South Africans.

PMID: 29411271 2018 Virus genes

Abstract: The basal core promoter mutations T1753C, A1762T, and G1764A were identified in the majority of sequences.

Qidong hepatitis B virus infection cohort: a 25-year prospective study in high risk area of primary liver cancer.

PMID: 29479565 2018 Hepatoma research

Introduction: By using capillary gel electrophoresis, we found that it was the short fragment, rather than larger fragment, contributing to the association of Pre-S deletion with HCC., In addition to the above novel findings, we also verified the association of some known HBV mutations, such as HBV pre-S2 start codon mutation, C1653T and T1753C, with HCC in Qidong.

Introduction: While A1762T/G1764A, C1653T, A799G, A987G, T1055A, pre-S deletion could be detected in the plasma long

The mutation of hepatitis B virus and the prognosis of hepatocellular carcinoma after surgery: a pilot study.

PMID: 29628773 2018 Cancer management and research

Method: According to the sequencing outcome, HBV genotype and mutations (including A1752T/G, T1753C, G1757A, A1762T/G1764A, C1766T, T1768A, A1775G, C1799G, A1846T, T1858C, G1896A, G1898A, G1899A, and Pre S deletion) were confirmed by the BLAST analysis (http://blast.ncbi.nlm.nih.gov/Blast.cgi).

Result: According to different mutation regions, A1752T/G, T1753C,

Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.

PMID: 28373061 2017 Virus research

Result: Among these clones, 13 (9 from HCC patients) harbored additional T1753C mutation (Fig. 1), 2 had additional C1766T mutation.

Result: In this regard 7 of the 12 highest replicating clones harbored either T1753C or C1766T.

Result: Our previous studies found that T1753C and C1766T could enhance the replication promoting effect of A1762T/G1764A hot spot mutations in genotype A.