Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Discussion: 116-127) of HBx are frequently altered in HBV-genotype C and B, but no significant sequence heterogeneity was noted in the epitopes of HBV-genotype D, except three mutations I127T (T1753C), K130M (A1762T) and V131I (G1764A), though H94Y (T1653C) was present with high frequencies in both LC and HCC (Table 3) as observed in previous study.