Method: We also considered eight VEMs (C139S, S/T140I, P142S, S/T143L/M, D144A/E/G/N, G145A/E/R, K141A/I/R and C147S) which are located within the epitope region neutralized by the HBV vaccine (aa139-147).
Result: We considered the distribution of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V, PMID: 29434654
2018
Infectious agents and cancer
Discussion: Several specific mutations, including G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R, have been reported as being related to the decrease of HBsAg secretion.
Hepatitis B virus infection in children of HBV-related chronic liver disease patients: a study of intra-familial HBV transmission.
Abstract: Recognized mutations associated with HBsAg detection and/or vaccination failure, T140I, T143S/M, G145R, and Y161F, were identified in 20 subjects; while mutations linked to HBeAg-defective variants, PC G1896A and BCP A1762T/G1764A, were found in 7 and 11 subjects, respectively.
Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
8Discussion: reported that major hydrophilic region (MHR) mutations in the ""a"" determinant region (G119R, C124Y, I126S, Q129R, S136P, C139R, T140I, K141E, D144A, and G145R) can significantly decrease virion, HBsAg detection and apparent occult HBV infection."
Characterization of Novel Hepatitis B Virus PreS/S-Gene Mutations in a Patient with Occult Hepatitis B Virus Infection.
Hepatitis B Virus Infection in Indonesia 15 Years After Adoption of a Universal Infant Vaccination Program: Possible Impacts of Low Birth Dose Coverage and a Vaccine-Escape Mutant.
PMID: 27402524
2016
The American journal of tropical medicine and hygiene
Abstract: Six samples (11.5%) had an amino acid substitution within the a determinant of the S gene region, and one sample had T140I that was suggested as a vaccine-escape mutant type.
Serological Patterns and Molecular Characterization of Occult Hepatitis B Virus Infection among Blood Donors.
Abstract: Mutations in the S region of HBV DNA included S114T, G119R, P120S, T125M, C139Y, T140I, C147W, T148A, A159V/G, E164D, V168A, and R169C.
Result: Variants were found in 30.4% (21/69) of cases with OBI and included S114T, G119R, P120S, T125M, C139Y, T140I,
[Occult hepatitis B virus infection in normal population, Xiamen].
PMID: 26081397
2015
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
1Abstract: 3 types of amino acid (AA) mutation (M133T, T140I, G145R) that influence ""a"" epitope conformation were observed in 9 subjects with occult HBV infection."
Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
PMID: 26202119
2015
Journal of clinical microbiology
Abstract: The major population of MHR variants causing impaired of HBsAg secretion (e.g., G119R, Q129R, T140I, and G145R) was detected only in advanced liver disease patients.
HBV mutation literature information.
PMID: 
2022
PloS one
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