literature

HBV mutation literature information.

Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.

PMID: 35415256 2022 Clinical and experimental hepatology

Table: T12S

Molecular characterization of HBV strains circulating among the treatment-naive HIV/HBV co-infected patients of eastern India.

PMID: 24587360 2014 PloS one

Abstract: The main amino acid substitutions within the MHC class II restricted T-cell epitope of HBcAg includes the T12S (15.8%) and T67N (12.3%) mutation and the V27I (10.5%) mutation in the MHC class I restricted T-cell epitope.

Result: Several amino acid substitutions were found within the immune-active region of the HBV core gene including the T12S (9/57, 15.8%) and T67N (7/57, 12.3%) mutation in the MHC class II restricted T-cell epitope of HBV core protein and the V27I (6/57, 10.5%) mutation in the MHC class I restricted T-cell epitope.

Figure: The major mutations in the MHC class I restricted (amino acids 18-27, 88-96, 130-140, 141-151) and MHC class II-restricted (amino

Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.

PMID: 25333524 2014 PloS one

Result: Overall three mutations in Th epitope (T12S, S35T, T67N) and one in CTL epitope (T147C) of core showed significant association with HCC (p<0.05) (Table 3).

Table: T12S

Discussion: While three mutations in Th epitopes (T12S, S35T, T67N), T147C in CTL epitope and two mutations I116L, P130Q in B cell epitopes showed significant association with disease severity (Table 3).

Naturally occurring core immune-escape and carboxy-terminal mutations runcations in patients with e antigen negative chronic hepatitis B.

PMID: 26201521 2012 Hepatology international

Abstract: CONCLUSION: Core immune-escape mutations cT12S, cS21T, cT67P, cE113D, and cP130T/Q are significantly higher in decompensated liver disease patients and could influence the severity of liver disease in HBeAg -ve CHB patients.

Abstract: Three core immune escape mutations were significantly higher in patients with coexisting precore stop codon compared with patients without

CTL escape mutations of core protein are more frequent in strains of HBeAg negative patients with low levels of HBV DNA.

PMID: 19748824 2009 Journal of clinical virology

Abstract: Substitutions for Ser(21) and Thr12Ser were associated with lower serum levels of HBV DNA (p<0.001).

Result: The Thr12Ser mutation was also found to be correlated with substitutions within CTL epitopes 18-27 (cc=0.43, p=0.0001), and 91-95 (cc=0.40, p=0.0002).

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