literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Table: T126N/I

Detection of Q129H Immune Escape Mutation in Apparently Healthy Hepatitis B Virus Carriers in Southwestern Nigeria.

PMID: 34210073 2021 Viruses

Introduction: In the following years, other mutations observed on the a-determinant, which are considered as immune escape variants, including T116N, P120S/E, I/T126A/N/I/S, Q129H/R, M133L, K141E, P142S, and D144A/E, have also been reported.

Characterization of Antigen Escape Mutations in Chronic HBV-Infected Patients in Upper Egypt.

PMID: 34234472 2021 Infection and drug resistance

8Discussion: Several other studies reported other substitutions in the ""a"" determinant region and associated with vaccine escape, such as T116N, P120S/E, I/T126A/N/I/S, Q129H/R, M133L, K141E, and D144A/E."

[HBV pol/S gene mutations in chronic hepatitis B patients receiving nucleoside/nucleotide analogues treatment].

PMID: 31130119 2019 Mikrobiyoloji bulteni

Abstract: Because of the HBV pol/S gene overlapping, in 27 patients immun-selected amino acid substitutions (sI110L, sT127P, sS114A, sT123A), in nine patients HBIg selected escape mutants (sP120R, sT123N, sE164D, sY134F, sQ129H, sT118A,

Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report.

PMID: 31542053 2019 Journal of medical case reports

Abstract: Sequencing analysis revealed the hepatitis B virus genotype D3 and the presence of two relevant immune-escape mutations (P120S and T126I) in the major hydrophilic region by analyzing the S region.

Conclusion: In contrast, by analyzing the S region, two relevant mutations, P120S and T126I, localized in the major hydrophilic region, an immune-active HBsAg domain, were found.

Evaluation of the pol/S Gene Overlapping Mutations in Chronic Hepatitis B Patients in Northern Cyprus.

PMID: 31880877 2019 Polish journal of microbiology

Result: The mutation patterns were sI110L + sS193L, sP120L + + sT123N + sT126I + sA128V + sY134H + sD144E + +sG145A, sT118A+sP127T, sI110L+

Analysis of HBV basal core promoter/precore gene variability in patients with HBV drug resistance and HIV co-infection in Northwest Ethiopia.

PMID: 29408943 2018 PloS one

Table: T126I

HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.

PMID: 27167598 2017 Antiviral therapy

Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (

HBV quasispecies composition in Lamivudine-failed chronic hepatitis B patients and its influence on virological response to Tenofovir-based rescue therapy.

PMID: 28303969 2017 Scientific reports

5Result:

Result: However, out of these 20 S-substitutions, 10 (sT114S, sT126I, sP127T, sN131T, sN143S, sY/S161F, sA194V, sI195M, sW196L and sR210N) remained significant after application of Benjamini-Hochberg correction (Table 2).

Hepatitis B genotypes and surface antigen mutants present in Pakistani blood donors.

PMID: 28582431 2017 PloS one

Result: Those omitted included R122K which is the determinant for subtyping HBsAg as ad versus ay, T126I for genotype C, A128V for genotype D2, and T131N for genotype A1.

Table: T126I

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