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 HBV mutation literature information.


  Analysis of entire hepatitis B virus genomes reveals reversion of mutations to wild type in natural infection, a 15 year follow-up study.
 PMID: 34902556       2022       Infection, genetics and evolution
Abstract: Some sequences from subject CC246 had predicted escape substitutions (T123N, G145R) in the surface protein in 2004, 2013 and 2019 but none of the sequences from 2007 had these changes.


  Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.
 PMID: 35390033       2022       PloS one
Table: T123A/N


  Occult and active hepatitis B virus detection in donated blood in Sao Paulo, Brazil.
 PMID: 33687074       2021       Transfusion
Abstract: Among them, T123N, G145A, and D144G high-impact immune escape mutations were identified.


  Analysis of the Physicochemical Properties, Replication and Pathophysiology of a Massively Glycosylated Hepatitis B Virus HBsAg Escape Mutant.
 PMID: 34835134       2021       Viruses
Introduction: Additional glycosylation sites on HBsAg other than the acceptor site at position N146, such as T123N or K160N, impaired or reduced the antibody recognition, respectively, while also reducing the virion formation.


  A Hyper-Glycosylation of HBV Surface Antigen Correlates with HBsAg-Negativity at Immunosuppression-Driven HBV Reactivation in Vivo and Hinders HBsAg Recognition in Vitro.
 PMID: 32102257       2020       Viruses
Abstract: These NLGSs are located in the major hydrophilic region of HBsAg (known to be the target of antibodies) and resulted from the single mutation T115N, T117N, T123N, N114ins, and from the triple mutant S113N+T131N+M133T.
Method: The following mutations associated with additional N-linked glycosylation sites were identified: 114N-ins, T115N, T117N, T123N, S113N+T131N+M133T.
Method: The newly identified mutations associated with additional N-linked glycosylation sites (114N-ins,


  [HBV pol/S gene mutations in chronic hepatitis B patients receiving nucleoside/nucleotide analogues treatment].
 PMID: 31130119       2019       Mikrobiyoloji bulteni
Abstract: Because of the HBV pol/S gene overlapping, in 27 patients immun-selected amino acid substitutions (sI110L, sT127P, sS114A, sT123A), in nine patients HBIg selected escape mutants (sP120R, sT123N, sE164D, sY134F, sQ129H, sT118A,


  Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains.
 PMID: 31516090       2019       Emerging microbes & infections
Discussion: Mutations T116N, T123N, G130N, and T131N + M133 T have been reported to reduce antigenicity and immunogenicity and rescue virion secretion in N146 mutants.
Discussion: The extremely low EIA reactivity observed for mutant TCT123-125NFT may be related to the combined effect of creation of an N-glycosylation site by T123N substitution and disruption of a putative disulfide bridge by the C124F substitution.


  Evaluation of the pol/S Gene Overlapping Mutations in Chronic Hepatitis B Patients in Northern Cyprus.
 PMID: 31880877       2019       Polish journal of microbiology
Result: The mutation patterns were sI110L + sS193L, sP120L + + sT123N + sT126I + sA128V + sY134H + sD144E + +sG145A, sT118A+sP127T, sI110L+


  Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot.
 PMID: 31880889       2019       Polish journal of microbiology
Table: T123N


  Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.
 PMID: 29859062       2018       BMC infectious diseases
Method: We determined the prevalence of 29 immune-associated escape mutations (sQ101K, sT114R, sP120S/T/A, sT123A/N, sT126N/S, sP127L, sA128V, sQ129R/N, sG130N/R, sT131I, sM133I/L/T,



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