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 HBV mutation literature information.


  Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.
 PMID: 35390033       2022       PloS one
Table: T123A/N


  Molecular and serological characterization of occult hepatitis B among blood donors in Maputo, Mozambique.
 PMID: 32997000       2020       Memorias do Instituto Oswaldo Cruz
Abstract: One escape mutation (T123A) associated with OBI and various amino acid substitutions for genotype A1 and E were observed.
Result: One escape mutation (T123A) associated with OBI in one sample was observed.
Table: T123A


  Molecular characterization of hepatitis B virus in blood donors in Botswana.
 PMID: 30382563       2019       Virus genes
Result: Twelve mutations including diagnostic escape mutations (sY100C, sR122K, sT123A, sC124R, sM133T), vaccine escape mutations (sT126N, sQ129R, sM133L, sF134V) and immunoglobulin therapy failure (sG119R, sG130N,  PMID: 31130119       2019       Mikrobiyoloji bulteni
Abstract: Because of the HBV pol/S gene overlapping, in 27 patients immun-selected amino acid substitutions (sI110L, sT127P, sS114A, sT123A), in nine patients HBIg selected escape mutants (sP120R, sT123N, sE164D, sY134F, sQ129H, sT118A,


  Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
 PMID: 31269905       2019       BMC infectious diseases
Result: P120Q (4.3%), T123A (4.3%), I126S, M133 T (8.7%), F134 L (4.3%) substitutions were found which might potentially affect HBsAg detection.


  Immune-escape mutations and stop-codons in HBsAg develop in a large proportion of patients with chronic HBV infection exposed to anti-HBV drugs in Europe.
 PMID: 29859062       2018       BMC infectious diseases
Method: We determined the prevalence of 29 immune-associated escape mutations (sQ101K, sT114R, sP120S/T/A, sT123A/N, sT126N/S, sP127L, sA128V, sQ129R/N, sG130N/R, sT131I, sM133I/L/T,


  HBV genotypes and drug resistance mutations in antiretroviral treatment-naive and treatment-experienced HBV-HIV-coinfected patients.
 PMID: 27167598       2017       Antiviral therapy
Method: The sequences were examined for known vaccine escape mutations (sG145R/A, sP142S, sI/T126A/N/I/S, sQ129H/R, sM133L, sD144A/E, sP120S/E, sK141E, sP134I, and sT116N), immunoprophylaxis escape mutations (


  Investigation of a Novel Hepatitis B Virus Surface Antigen (HBsAg) Escape Mutant Affecting Immunogenicity.
 PMID: 28045894       2017       PloS one
Discussion: Antigenic index (Ai) values of four or more amino acids around amino acid position 123 were altered by a magnitude of -0.4 to +0.2 or more by the T123A or T123N mutations, respectively.


  Discordant diagnostic results due to a hepatitis B virus T123A HBsAg mutant.
 PMID: 27133305       2016       Diagnostic microbiology and infectious disease
Abstract: Such discordance has been observed repeatedly in Canada with samples having a mutation at HBsAg codon 123 (sT123A).
Abstract: The sT123A mutation leads to loss of detection by immunoassays commonly used in Canadian diagnostic laboratories, which may produce misleading results and diagnoses.


  Ultradeep Sequencing for Detection of Quasispecies Variants in the Major Hydrophilic Region of Hepatitis B Virus in Indonesian Patients.
 PMID: 26202119       2015       Journal of clinical microbiology
Abstract: The most frequent MHR variants related to immune evasion in the major and intermediate populations were P120Q/T, T123A, P127T, Q129H/R, M133L/T, and G145R.



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