Abstract: Specifically, the prevalence rates of sT118 K, sK122R, and sV168A were increased in OBI patients.
Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.
PMID: 32994690
2020
World journal of gastroenterology
Abstract: In particular, these mutations were sQ101H/K/R, sS114A/L/T, sT118A/K/M/R/S/V, sP120A/L/Q/S/T, sT/I126A/N/P/S, sM133I/L/T, sC137W/Y, sG145A/R, and sA159G/V.
Result: In particular, mutations were detected in 67/63
Nearly half of Ultrio plus NAT non-discriminated reactive blood donors were identified as occult HBV infection in South China.
Abstract: Most OBI strains were wild-type HBV, but some substitutions V168A, S174 N, V177A, Q129R/L/H, G145A/R in S region of genotype B (OBIB) and T47K/V/A, P49H/L, Q101R/H/K, S174 N, L175S, V177A, T118 M/R/K, G145R/A/K/E, R160K/N in S region of genotype C (OBIC) strains were identified in high frequency.
T
Hepatitis B virus reactivation sustained by a hepatitis B virus surface antigen immune-escape mutant isolate in a patient who was hepatitis B core antibody positive during treatment with sofosbuvir and velpatasvir for hepatitis C virus infection: a case report.
PMID: 31542053
2019
Journal of medical case reports
Discussion: In the first case, genome sequencing revealed a T118K mutation in the S region, but in contrast to our description, the HBV viremia occurred 5 months after the EOT with daclatasvir and asunaprevir.
Deep sequencing of hepatitis B surface antigen gene in the preserved umbilical cords in immunoprophylaxis failure against mother-to-child HBV transmission.
Conclusion: G44E, P56L, F93S, C107Y, L110P, S117 N, T118K, D144A and W167 L were detected in only one sample.
Table: T118K
Impact of immune escape mutations and N-linked glycosylation on the secretion of hepatitis B virus virions and subviral particles: Role of the small envelope protein.
Discussion: The M133T mutation could efficiently rescue virion secretion of the I110M, T118K, G119E, P127S, G145R, and R169H mutants to nearly WT level, and moderately improve virion secretion of the G130R, C138Y, C147R, and C149R mutants.
Discussion: The T118K mutant actually had increased HBsAg release.
Expansion of viral variants associated with immune escape and impaired virion secretion in patients with HBV reactivation after resolved infection.
Abstract: Furthermore, reactivated HBV in 11 of 16 (69%) non-HSCT cases possessed substitutions associated with impaired virion secretion, including E2G, L77R, L98V, T118K, and Q129H in the S region, and M1I/V in the PreS2 region.
Result: Amino acid substitutions associated with immune escape, such as sT118K (n = 3), sG145A (n = 3), and sG145R (n = 1) variants, were abundant, especially in non- PMID: 28236303
2017
Transfusion
Abstract: Specifically, the incidence of five OBI-related major hydrophilic region mutations (sS117T, sT118K, sT131N, sT134Y/L, and sD144E) was significantly higher in blood donors with OBI than in controls.
Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India.
Discussion: On the other hand, some HBV/A1 isolates carried the sT118K mutation in their major hydrophilic loop, which has been previously reported to be associated with failure in HBsAg detection.
A case of acute hepatitis B in a chronic hepatitis C patient after daclatasvir and asunaprevir combination therapy: hepatitis B virus reactivation or acute self-limited hepatitis?
PMID: 27329484
2016
Clinical journal of gastroenterology
Abstract: T118 K mutation at the S region as an immune escape mutant was identified.
HBV mutation literature information.
PMID: 
2020
Journal of clinical virology
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