literature

HBV mutation literature information.

Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.

PMID: 29287068 2017 PloS one

Discussion: G529A and T1078G were located in the RT domain of polymerase, which possesses RT and DNA-dependent DNA polymerase activity.

Discussion: T1078G, which is located in the non-overlapping region of the RT domain, can induce an amino acid change from Ser to Ala (rt

Discussion: Further functional research is required to determine whether the amino acid residue changes induced by G529A and T1078G would result in altered RT activity so as to modify HBV replication and cell proliferation in HCC.

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