Abstract: A series of novel PLC-related mutations including A2159G, A2189C and G2203W at the C gene, A799G, A987G and T1055A at the P gene of HBV genome were identified by using samples from the cohort.
Introduction:
Introduction: These mutations include A2159G, A2189C and G2203W at C gene, A799G, A987G and T1055A at P gene, and A1479T at X gene.
Mutations in hepatitis B virus polymerase are associated with the postoperative survival of hepatocellular carcinoma patients.
Abstract: A pooled analysis of samples revealed that A799G, A987G, and T1055A were independent risk factors for HCC, with adjusted odds ratios of 5.53 [95% confidence interval (CI), 1.69-18.10], 4.20 (95%CI, 1.15-15.35), and 3.78 (95%CI, 1.45-9.86), respectively.
Abstract: RESULTS: There were 15 candidate mutations identified from the discovery set, with A799G and T1055A being consistently associated with HCC across all studies.
Result: A799G and T1055A are missense mutations resulting in aa substitutions of I224V and M309K, and
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
Discussion: These mutations might not affect HBsAg but could alter polymerase activity as another mutation in this region, T1055A has been reported to affect the conformation of two helices and impair HBV DNA-primer interaction.
HBV mutation literature information.
PMID: 
2018
Hepatoma research
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