literature

HBV mutation literature information.

Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.

PMID: 35415256 2022 Clinical and experimental hepatology

Table: S87G

Naturally occurring core protein mutations compensate for the reduced replication fitness of a lamivudine-resistant HBV isolate.

PMID: 30902704 2019 Antiviral research

Method: The core gene point mutations (P5T, S35T, S87G, I97L, Q177K) and the reversion mutations (T5P, T35S, Q79P, D83E, G87S, L97I, K177Q) were individually introduced into pCMVHBV-WT and pCMVHBV-GYF, respectively, by using QuikChange Site-directed Mutagenesis Kit (Stratagene) or Q5 Site-directed Mutagenesis Kit (NEB).

Method: The PCR fragment containing the combined 6 core mutations (P5T/S35T/P79Q/

PMID: 30406036 2018 Frontiers in cellular and infection microbiology

Table: S87G

Potential Susceptibility Mutations in C Gene for Hepatitis B-Related Hepatocellular Carcinoma Identified by a Two-Stage Study in Qidong, China.

PMID: 27727182 2016 International journal of molecular sciences

Discussion: A2159G and A2189Y mutations are missense mutations resulting in an amino acid change of HBcAg codons 87 (S87G) and 97 (I97L/F), respectively.

Hepatitis B virus core protein variations differ in tumor and adjacent nontumor tissues from patients with hepatocellular carcinoma.

PMID: 21325784 2012 Intervirology

Abstract: The most frequently occurring mutations in rank were codon P130T (38.8%), I97L (37.8%) and S87G (23.5%).

[Detection and analysis of gene polymorphism in hepatitis B virus C region].

PMID: 22097597 2011 Zhonghua shi yan he lin chuang bing du xue za zhi

Abstract: Four hepatitis B patients had mutation nt1896 g-->a, and another 4 patients had 2 mutations, namely, S87G and I97F (or 197L) in HBcAg CTL recognition episome.

Hepatitis B virus core protein with hot-spot mutations inhibit MxA gene transcription but has no effect on inhibition of virus replication by interferon alpha.

PMID: 20959021 2010 Virology journal

Abstract: However, in Huh7 cells stably expressing WT or the mutated HBc proteins (L60V, S87G or I97L), IFN-alpha could inhibit the extra- and intracellular HBV DNA level and HBsAg secretion to a similar level compared to that in cells transfected with control plasmids.

Abstract: In this study, we investigated whether HBc protein mutations at hot spots (L60V, S87G and I97L) could still inhibit MxA transcription and the potential significance of this inhibition in virus replication in vitro.

Abstract: Moreover, the inhibitory effect on MxA gene transcription by the WT or mutated HBc proteins (L60V,

PMID: 8952268 1996 Kansenshogaku zasshi

Abstract: The analysis of nucleotide sequences (codon 27-100) of HBV DNA in anti-HBe positive sera showed that there were two hypervariable segments of codon 31-49 and codon 87-97, where amino acid substitutions of L31I, S49T, S87G/N, K96N and I87F/1 frequently occurred regardless of the presence or absence of the mutation in the pre-core region.

Browser Board

Co-occurred Entities

Filtrator