literature

HBV mutation literature information.

Mutations in the HBV PreS/S gene related to hepatocellular carcinoma in Vietnamese chronic HBV-infected patients.

PMID: 35390033 2022 PloS one

Result: Among them, 4 point-mutations W4P/R/Y, S5L/T, A90T/S/G, and L108V/I were observed with the significantly higher rates in the HCC group compared to non-HCC group: W4P/R/Y (12.2% vs 2%, p = 0.005), S5L/T (6.1% vs 1%, p = 0.055), A90T/S/G (6.1% vs 0.5%, p = 0.026) and L108V/I (6.1% vs 0.5%, p = 0.026) (Table 2).

Table: S5L/T

Discussion: They were W4P/R/Y and S5L/T (p = 0.055) on the NTCP region;

Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection.

PMID: 29434654 2018 Infectious agents and cancer

Result: The different mutations detected were W4R, S5A/P/T, L30S, G35R, H51P/R, E54K, A60V, W77R/Stop, I84T, N98 K/T, G102R, Q118R/Stop, N123D and S124F/P.

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