Abstract: Results confirmed by multivariable analysis correcting for patients'demographics, HBV-DNA, ALT and infection-status.In genotype-D, specific C-terminus mutations (
V190A-
S204N-
Y206C-
Y206F-
S210N) significantly correlate with
HBsAg<1000IU/ml(P-value from <0.001 to 0.04).
Abstract: These mutations lie in divergent pathways involving other
HBsAg C-terminus mutations:
V190A +
F220L (Phi = 0.41, P = 0.003),
S204N +
L205P (Phi = 0.36, P = 0.005),
Y206F +
S210R (Phi = 0.47, P < 0.001) and
S210N +