literature

HBV mutation literature information.

Precore/core mutations of hepatitis B virus genotype D arising in different states of infection.

PMID: 35415256 2022 Clinical and experimental hepatology

Discussion: However, in spite of their prevalence, our data showed that E80Q/D, E113D/Q, S181P/R and Q182K/*Stop variations were not statistically significantly different among the groups.

Discussion: There were some variations such as E77Q, E113Q, S181P/H and Q182K/*Stop outside of the epitope regions which have previously been reported to accumulate with disease progression.

Mutations in Core Gene Region of Hepatitis B Virus in Patients with Chronic Hepatitis B.

PMID: 29739114 2018 Clinical laboratory

Abstract: Some types of mutations (V27I, R47H, Y132I, R174STOP, S181P, Q182K) were only detected in subjects with liver cirrhosis.

The Correlation Between Hepatitis B Virus Precore/Core Mutations and the Progression of Severe Liver Disease.

PMID: 30406036 2018 Frontiers in cellular and infection microbiology

Table: S181P

Sequence analysis and functional characterization of full-length hepatitis B virus genomes from Korean cirrhotic patients with or without liver cancer.

PMID: 28373061 2017 Virus research

Result: In addition, the E180G, S181P, and Q182K missense mutations were identified in 12 clones derived from 5 HCC patients but only 3 clones from 2 non-HCC patients (Table 2).

Discussion: The C-terminal 10 residues of the core protein are dispensable for HBV replication, and the high replication capacity of clones 4.2, 4.9, 13.2, and 5.1 suggests that the E180G, S181P, and Q182K mutations present in these clones do not markedly suppress genome replication.

Discussion: These include E180G, S181P, Q182K, and

Filtrator