Result: Moreover, an
S130F/L mutation in the
pre-S2 region of the
LC samples (22.22%; 2/9) and a substitution at the start codon of the
pre-S2 (Met1R) region in 11.76% (2/17) of the
HCC cases were also detected, with a non-significant difference (p = 0.46).
Discussion: Certain substitutions, including
L11Q,
A28T and
K38R, at the
pre-S1 region, and
S130F/L in the
pre-S2 region, were detected significantly more frequently in the ASC individuals than in those with
LC/
HBV mutation literature information.
PMID: 
2019
Clinical and experimental hepatology
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