HBV mutation literature information.


  Substitution at rt269 in Hepatitis B Virus Polymerase Is a Compensatory Mutation Associated with Multi-Drug Resistance.
 PMID: 26322642       2015       PloS one
Discussion: The compensatory mutations discovered thus far in the YMDD mutants include rtL180M, L80I/V, V173L, S117F, and L229F/V.


  Identification of hepatitis B virus rtS117F substitution as a compensatory mutation for rtM204I during lamivudine therapy.
 PMID: 22001270       2012       The Journal of antimicrobial chemotherapy
Abstract: Additionally, virion and hepatitis B surface antigen secretion of the rtS117F mutant was significantly impaired.
Abstract: CONCLUSIONS: The rtS117F substitution served as a compensatory mutation for rtM204I.
Abstract: Emergence of the rtS117F mutation in lamivudine-resistant patients carrying rtM204I was associated with increased hepatitis activities.



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