Abstract: Both the A194T and a quadruple mutation CYEI (S106C, H126Y, D134E and L269I) in hepatitis B virus (HBV) polymerase reverse transcriptase domain (pol/RT) are suggested to be associated with treatment failure with tenofovir disoproxil fumarate (TDF).
Virologic analysis of tenofovir resistance in a patient with chronic hepatitis B experiencing viral breakthrough during combination treatment with tenofovir disoproxil fumarate and entecavir.
Abstract: A recent Korean report showed that two patients with viral breakthrough during treatment with TDF-containing regimens were found to carry five reverse transcriptase (rt) mutations ([rt]S106C[C], rtH126Y[Y], rtD134E[E], rtM204I/V, and rtL269I [I]), with the C, Y, E, and I mutations being associated with tenofovir resistance.
Abstract: Four mutations (rtS106C, rtD134N/S[N/S], rt
Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes.
PMID: 33562603
2021
International journal of molecular sciences
Introduction: Despite its high genetic barrier to resistance, we have previously reported that a novel quadruple mutation (CYEI; rtS106C (C), rtH126Y (Y), rtD134E (E), and rtL269I (I)) is associated with tenofovir resistance.
Method: Two clones (CYEI: rtS106C (C) + rtH126Y (Y) + rtD134E (E) + rtL269I (I) and CYELMVI: rtS106C (C) +
Global prevalence and phylogeny of hepatitis B virus (HBV) drug and vaccine resistance mutations.
Method: For this analysis, we considered a total of 12 RAMs (S106C/G, D134E, R153W/Q, V173L, L180M, A181T/V, A194T, A200V, M204I/V, L217R, L229V/W and I269L).
Result: Compared to all other genotypes, genotype C had the highest prevalence of individual RAMs S106C/G, DH/N134E and I269L, and Asia had the highest prevalence of these individual RAMs S106C/G, DH/N134
Investigation of immune escape-associated mutations of hepatitis B virus in patients harboring hepatitis B virus drug-resistance mutations.
PMID: 32994690
2020
World journal of gastroenterology
Introduction: In addition, rtS106C+rtH126Y+rtD134E+rtL269I quadruple mutations have recently been reported to confer TDF resistance.
Identification of a quadruple mutation that confers tenofovir resistance in chronic hepatitis B patients.
Abstract: RESULTS: Five mutations (rtS106C [C], rtH126Y [Y], rtD134E [E], rtM204I/V, and rtL269I [I]) were commonly found in viral isolates from 2 patients.
Effects of amino acid substitutions in hepatitis B virus surface protein on virion secretion, antigenicity, HBsAg and viral DNA.
Result: Due to the overlapping nature of the S and RT gene regions, mutations in the S gene may result in concomitant mutations in RT, such as sC69*/rtS78T, sL98V/rtS106C and sG145R/rtR153Q, potentially affecting RT activity and HBV replication.
Characterization of the occult hepatitis B virus variants circulating among the blood donors from eastern India.
Abstract: rtS106C, rtD134E/G/N/S and A-B interdomain mutations may be associated with necro-inflammation, immune response and cirrhosis development at ages older than 40.
Abstract: The naturally occurring mutation, rtS106C mutation was higher in chronic hepatitis B patients (14/100, 14.0%) and cirrhotic patients (14/100, 14.0%) than that in hepatocellular carcinoma patients (4/100, 4.0%, P = 0.013).
ViMRT
HBV mutation literature information.
PMID: 
2021
Journal of viral hepatitis
